Cited 14 times in
A nomogram constructed using intraoperative ex vivo shear-wave elastography precisely predicts metastasis of sentinel lymph nodes in breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박소은 | - |
dc.contributor.author | 배숭준 | - |
dc.contributor.author | 손은주 | - |
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 육지현 | - |
dc.contributor.author | 이학우 | - |
dc.contributor.author | 정준 | - |
dc.contributor.author | 차치환 | - |
dc.date.accessioned | 2020-02-26T06:44:35Z | - |
dc.date.available | 2020-02-26T06:44:35Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175271 | - |
dc.description.abstract | OBJECTIVE: To develop a nomogram and validate its use for the intraoperative evaluation of nodal metastasis using shear-wave elastography (SWE) elasticity values and nodal size METHODS: We constructed a nomogram to predict metastasis using ex vivo SWE values and ultrasound features of 228 axillary LNs from fifty-five patients. We validated its use in an independent cohort comprising 80 patients. In the validation cohort, a total of 217 sentinel LNs were included. RESULTS: We developed the nomogram using the nodal size and elasticity values of the development cohort to predict LN metastasis; the area under the curve (AUC) was 0.856 (95% confidence interval (CI), 0.783-0.929). In the validation cohort, 15 (7%) LNs were metastatic, and 202 (93%) were non-metastatic. The mean stiffness (23.54 and 10.41 kPa, p = 0.005) and elasticity ratio (3.24 and 1.49, p = 0.028) were significantly higher in the metastatic LNs than those in the non-metastatic LNs. However, the mean size of the metastatic LNs was not significantly larger than that of the non-metastatic LNs (8.70 mm vs 7.20 mm, respectively; p = 0.123). The AUC was 0.791 (95% CI, 0.668-0.915) in the validation cohort, and the calibration plots of the nomogram showed good agreement. CONCLUSIONS: We developed a well-validated nomogram to predict LN metastasis. This nomogram, mainly based on ex vivo SWE values, can help evaluate nodal metastasis during surgery. KEY POINTS: • A nomogram was developed based on axillary LN size and ex vivo SWE values such as mean stiffness and elasticity ratio to easily predict axillary LN metastasis during breast cancer surgery. • The constructed nomogram presented high predictive performance of sentinel LN metastasis with an independent cohort. • This nomogram can reduce unnecessary intraoperative frozen section which increases the surgical time and costs in breast cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | A nomogram constructed using intraoperative ex vivo shear-wave elastography precisely predicts metastasis of sentinel lymph nodes in breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Soong June Bae | - |
dc.contributor.googleauthor | Ji Hyun Youk | - |
dc.contributor.googleauthor | Chang Ik Yoon | - |
dc.contributor.googleauthor | Soeun Park | - |
dc.contributor.googleauthor | Chi Hwan Cha | - |
dc.contributor.googleauthor | Hak Woo Lee | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Seung Ah Lee | - |
dc.contributor.googleauthor | Eun Ju Son | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.1007/s00330-019-06473-5 | - |
dc.contributor.localId | A05726 | - |
dc.contributor.localId | A05345 | - |
dc.contributor.localId | A01988 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A02537 | - |
dc.contributor.localId | A05015 | - |
dc.contributor.localId | A03727 | - |
dc.contributor.localId | A05731 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 31696293 | - |
dc.subject.keyword | Breast neoplasm | - |
dc.subject.keyword | Elasticity imaging techniques | - |
dc.subject.keyword | Lymphatic metastasis | - |
dc.subject.keyword | Nomogram | - |
dc.contributor.alternativeName | Park, So Eun | - |
dc.contributor.affiliatedAuthor | 박소은 | - |
dc.contributor.affiliatedAuthor | 배숭준 | - |
dc.contributor.affiliatedAuthor | 손은주 | - |
dc.contributor.affiliatedAuthor | 안성귀 | - |
dc.contributor.affiliatedAuthor | 육지현 | - |
dc.contributor.affiliatedAuthor | 이학우 | - |
dc.contributor.affiliatedAuthor | 정준 | - |
dc.contributor.affiliatedAuthor | 차치환 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 789 | - |
dc.citation.endPage | 797 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.30(2) : 789-797, 2020 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.