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Gamma Knife Radiosurgery for Choroidal Hemangioma: A Single-Institute Series

 Kyu Seon Chung  ;  Won Seok Chang  ;  Jong Hee Chang  ;  Sung Chul Lee  ;  Jin Woo Chang  ;  Yong Gou Park  ;  Hyun Ho Jung 
 WORLD NEUROSURGERY, Vol.133 : e129-e134, 2020 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Child ; Choroid Neoplasms/complications ; Choroid Neoplasms/pathology ; Choroid Neoplasms/surgery* ; Choroid Neoplasms/therapy ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Hemangioma/complications ; Hemangioma/pathology ; Hemangioma/surgery* ; Hemangioma/therapy ; Humans ; Male ; Middle Aged ; Radiosurgery* ; Treatment Outcome ; Tumor Burden ; Vision Disorders/etiology ; Young Adult
Choroidal hemangioma ; Circumscribed type ; Diffuse type with Sturge-Weber syndrome ; Gamma knife radiosurgery
OBJECTIVE: Choroidal hemangioma (CH) is a benign vascular tumor that induces subretinal fluid collection or exudative retinal detachment and consequent visual symptoms. Current standard treatments for CH include cryotherapy, diathermy, photocoagulation, photodynamic therapy, transpupillary thermotherapy, and radiation therapy. Stereotactic radiosurgery has recently been applied to the treatment of CH because of its characteristic stiff dose-fall-off and accuracy. We have adopted gamma knife radiosurgery (GKRS) to treat CH and have retrospectively assessed tumor volume reductions and improvements to visual acuity achieved thereby. METHODS: Fourteen patients with CHs were treated with GKRS from November 2006 to December 2017. Eight patients had circumscribed CH, and 6 exhibited diffuse CHs and were diagnosed with Sturge-Weber syndrome. The mean age of patients was 27.1 years (range: 8-68 years) and the mean duration of clinical or radiological follow-up was 40.2 months (range: 5-105 months). The mean volume of the tumors at the time of GKRS was 533.5 mm3 (range: 124-1150 mm3), and the mean prescribed marginal dose was 11.6 Gy (range: 10-16 Gy) with 50% isodose lines. RESULTS: The tumor volume decreased by the last follow-up in all patients. The visual acuity improved in 9 patients (64%) and decreased in 1 (7%). Six patients (43%) required trans-pars plana vitrectomy before or after GKRS. There were no symptomatic complications from radiation injury during the follow-up periods. CONCLUSIONS: GKRS could be an acceptable alternative treatment for symptomatic CH when standard therapy is not feasible.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Gou(박용구)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Hyun Ho(정현호)
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