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CTCF deficiency causes expansion of the sensory domain in the mouse cochlea

Authors
 Ji-Hyun Ma  ;  Hyoung-Pyo Kim  ;  Jeong-Oh Shin 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.512(4) : 896-901, 2019 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2019
Keywords
CCCTC-Binding factor (CTCF) ; Hair cell differentiation ; Inner ear development ; Otic sensory specification
Abstract
The cochlea in the mammalian inner ear is a sensitive and sharply organized sound-detecting structure. The proper specification of neurosensory-competent domain in the otic epithelium is required for the formation of mature neuronal and sensory domains. Genetic studies have provided many insights into inner ear development, but there have been few epigenetic studies of inner ear development. CTCF is an epigenetic factor that plays a pivotal role in the organization of global chromatin conformation. To determine the role of CTCF in the otic sensory formation, we made a conditional knockout of Ctcf in the developing otic epithelium by crossing Ctcffl/fl mice with Pax2-Cre mice. Ctcf deficiency resulted in extra rows of auditory hair cells in the shortened cochlea on mouse embryonic day 14.5 (E14.5) and E17.5. The massive and ectopic expression of sensory specifiers such as Jag1 and Sox2 indicated that the sensory domain was expanded in the Ctcf-deficient cochlea. Other regulators of the sensory domain such as Bmp4, Gata3, and Fgf10 were not affected. These results suggest that CTCF plays a role in the regulation of the sensory domain in mammalian cochlear development.
Full Text
https://www.sciencedirect.com/science/article/pii/S0006291X19305182
DOI
10.1016/j.bbrc.2019.03.127
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
Ma, Ji Hyun(마지현) ORCID logo https://orcid.org/0000-0002-7215-9040
Shin, Jeong Oh(신정오) ORCID logo https://orcid.org/0000-0002-6935-0936
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175205
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