0 123

Cited 2 times in

Twist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis

Authors
 YOON AH CHO  ;  EUN KYUNG KIM  ;  BYOUNG CHUL CHO  ;  YOON WOO KOH  ;  SUN OCH YOON 
Citation
 ANTICANCER RESEARCH, Vol.39(11) : 6307-6316, 2019 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
2019
MeSH
Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/secondary* ; Carcinoma, Squamous Cell/virology ; Cyclin-Dependent Kinase Inhibitor p16/metabolism* ; Epithelial-Mesenchymal Transition* ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Nuclear Proteins/metabolism* ; Oropharyngeal Neoplasms/metabolism ; Oropharyngeal Neoplasms/mortality ; Oropharyngeal Neoplasms/pathology* ; Oropharyngeal Neoplasms/virology ; Papillomavirus Infections/complications ; Progression-Free Survival ; Snail Family Transcription Factors/metabolism* ; Tumor Burden ; Twist-Related Protein 1/metabolism*
Keywords
Oropharyngeal squamous cell carcinoma ; epithelial-to-mesenchymal transition ; head and neck squamous cell carcinoma ; lymph node metastasis ; tumor budding
Abstract
BACKGROUND/AIM: Oropharyngeal squamous cell carcinoma (OPSCC) could be clinically undetectable despite the relatively large size of lymph node metastases. Here, we aimed to elucidate the correlation of p16 expression with epithelial-to-mesenchymal transition (EMT) markers. PATIENTS AND METHODS: Radically resected 121 OPSCC and 270 non-OPSCC tissue samples were included in the analysis, and p16, Twist, and Snail/Slug immunohistochemistry was performed. RESULTS: Compared to non-OPSCCs, OPSCCs were significantly associated with lymphovascular invasion, lymph node metastasis, larger maximal diameter of metastatic foci in the lymph nodes, and p16 expression. In addition, p16 expression correlated with high Twist and Snail/Slug expression. CONCLUSION: Expression of EMT markers, such as Twist and Snail/Slug, is related to p16 expression in OPSCC. This might indicate that HPV infection in OPSCCs alters the expression of EMT markers and results in metastases.
Full Text
http://ar.iiarjournals.org/content/39/11/6307.long
DOI
10.21873/anticanres.13841
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Kim, Eun Kyung(김은경)
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175203
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links