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Twist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis

DC Field Value Language
dc.contributor.author고윤우-
dc.contributor.author김은경-
dc.contributor.author윤선옥-
dc.contributor.author조병철-
dc.date.accessioned2020-02-26T06:34:27Z-
dc.date.available2020-02-26T06:34:27Z-
dc.date.issued2019-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175203-
dc.description.abstractBACKGROUND/AIM: Oropharyngeal squamous cell carcinoma (OPSCC) could be clinically undetectable despite the relatively large size of lymph node metastases. Here, we aimed to elucidate the correlation of p16 expression with epithelial-to-mesenchymal transition (EMT) markers. PATIENTS AND METHODS: Radically resected 121 OPSCC and 270 non-OPSCC tissue samples were included in the analysis, and p16, Twist, and Snail/Slug immunohistochemistry was performed. RESULTS: Compared to non-OPSCCs, OPSCCs were significantly associated with lymphovascular invasion, lymph node metastasis, larger maximal diameter of metastatic foci in the lymph nodes, and p16 expression. In addition, p16 expression correlated with high Twist and Snail/Slug expression. CONCLUSION: Expression of EMT markers, such as Twist and Snail/Slug, is related to p16 expression in OPSCC. This might indicate that HPV infection in OPSCCs alters the expression of EMT markers and results in metastases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfANTICANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHCarcinoma, Squamous Cell/metabolism-
dc.subject.MESHCarcinoma, Squamous Cell/mortality-
dc.subject.MESHCarcinoma, Squamous Cell/secondary*-
dc.subject.MESHCarcinoma, Squamous Cell/virology-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p16/metabolism*-
dc.subject.MESHEpithelial-Mesenchymal Transition*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNuclear Proteins/metabolism*-
dc.subject.MESHOropharyngeal Neoplasms/metabolism-
dc.subject.MESHOropharyngeal Neoplasms/mortality-
dc.subject.MESHOropharyngeal Neoplasms/pathology*-
dc.subject.MESHOropharyngeal Neoplasms/virology-
dc.subject.MESHPapillomavirus Infections/complications-
dc.subject.MESHProgression-Free Survival-
dc.subject.MESHSnail Family Transcription Factors/metabolism*-
dc.subject.MESHTumor Burden-
dc.subject.MESHTwist-Related Protein 1/metabolism*-
dc.titleTwist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorYOON AH CHO-
dc.contributor.googleauthorEUN KYUNG KIM-
dc.contributor.googleauthorBYOUNG CHUL CHO-
dc.contributor.googleauthorYOON WOO KOH-
dc.contributor.googleauthorSUN OCH YOON-
dc.identifier.doi10.21873/anticanres.13841-
dc.contributor.localIdA00133-
dc.contributor.localIdA04868-
dc.contributor.localIdA02566-
dc.contributor.localIdA03822-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid31704861-
dc.identifier.urlhttp://ar.iiarjournals.org/content/39/11/6307.long-
dc.subject.keywordOropharyngeal squamous cell carcinoma-
dc.subject.keywordepithelial-to-mesenchymal transition-
dc.subject.keywordhead and neck squamous cell carcinoma-
dc.subject.keywordlymph node metastasis-
dc.subject.keywordtumor budding-
dc.contributor.alternativeNameKho, Yoon Woo-
dc.contributor.affiliatedAuthor고윤우-
dc.contributor.affiliatedAuthor김은경-
dc.contributor.affiliatedAuthor윤선옥-
dc.contributor.affiliatedAuthor조병철-
dc.citation.volume39-
dc.citation.number11-
dc.citation.startPage6307-
dc.citation.endPage6316-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, Vol.39(11) : 6307-6316, 2019-
dc.identifier.rimsid63604-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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