Cited 13 times in
Twist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis
DC Field | Value | Language |
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dc.contributor.author | 고윤우 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 윤선옥 | - |
dc.contributor.author | 조병철 | - |
dc.date.accessioned | 2020-02-26T06:34:27Z | - |
dc.date.available | 2020-02-26T06:34:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175203 | - |
dc.description.abstract | BACKGROUND/AIM: Oropharyngeal squamous cell carcinoma (OPSCC) could be clinically undetectable despite the relatively large size of lymph node metastases. Here, we aimed to elucidate the correlation of p16 expression with epithelial-to-mesenchymal transition (EMT) markers. PATIENTS AND METHODS: Radically resected 121 OPSCC and 270 non-OPSCC tissue samples were included in the analysis, and p16, Twist, and Snail/Slug immunohistochemistry was performed. RESULTS: Compared to non-OPSCCs, OPSCCs were significantly associated with lymphovascular invasion, lymph node metastasis, larger maximal diameter of metastatic foci in the lymph nodes, and p16 expression. In addition, p16 expression correlated with high Twist and Snail/Slug expression. CONCLUSION: Expression of EMT markers, such as Twist and Snail/Slug, is related to p16 expression in OPSCC. This might indicate that HPV infection in OPSCCs alters the expression of EMT markers and results in metastases. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell/metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell/mortality | - |
dc.subject.MESH | Carcinoma, Squamous Cell/secondary* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/virology | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p16/metabolism* | - |
dc.subject.MESH | Epithelial-Mesenchymal Transition* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lymph Nodes/pathology* | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Nuclear Proteins/metabolism* | - |
dc.subject.MESH | Oropharyngeal Neoplasms/metabolism | - |
dc.subject.MESH | Oropharyngeal Neoplasms/mortality | - |
dc.subject.MESH | Oropharyngeal Neoplasms/pathology* | - |
dc.subject.MESH | Oropharyngeal Neoplasms/virology | - |
dc.subject.MESH | Papillomavirus Infections/complications | - |
dc.subject.MESH | Progression-Free Survival | - |
dc.subject.MESH | Snail Family Transcription Factors/metabolism* | - |
dc.subject.MESH | Tumor Burden | - |
dc.subject.MESH | Twist-Related Protein 1/metabolism* | - |
dc.title | Twist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | YOON AH CHO | - |
dc.contributor.googleauthor | EUN KYUNG KIM | - |
dc.contributor.googleauthor | BYOUNG CHUL CHO | - |
dc.contributor.googleauthor | YOON WOO KOH | - |
dc.contributor.googleauthor | SUN OCH YOON | - |
dc.identifier.doi | 10.21873/anticanres.13841 | - |
dc.contributor.localId | A00133 | - |
dc.contributor.localId | A04868 | - |
dc.contributor.localId | A02566 | - |
dc.contributor.localId | A03822 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 31704861 | - |
dc.identifier.url | http://ar.iiarjournals.org/content/39/11/6307.long | - |
dc.subject.keyword | Oropharyngeal squamous cell carcinoma | - |
dc.subject.keyword | epithelial-to-mesenchymal transition | - |
dc.subject.keyword | head and neck squamous cell carcinoma | - |
dc.subject.keyword | lymph node metastasis | - |
dc.subject.keyword | tumor budding | - |
dc.contributor.alternativeName | Kho, Yoon Woo | - |
dc.contributor.affiliatedAuthor | 고윤우 | - |
dc.contributor.affiliatedAuthor | 김은경 | - |
dc.contributor.affiliatedAuthor | 윤선옥 | - |
dc.contributor.affiliatedAuthor | 조병철 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6307 | - |
dc.citation.endPage | 6316 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.39(11) : 6307-6316, 2019 | - |
dc.identifier.rimsid | 63604 | - |
dc.type.rims | ART | - |
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