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Noninvasive Biomarker for Predicting Treatment Response to Concurrent Chemoradiotherapy in Patients with Hepatocellular Carcinoma

DC FieldValueLanguage
dc.contributor.author김명진-
dc.contributor.author박미숙-
dc.contributor.author박준용-
dc.contributor.author성진실-
dc.contributor.author정용은-
dc.contributor.author최진영-
dc.date.accessioned2020-02-26T06:33:44Z-
dc.date.available2020-02-26T06:33:44Z-
dc.date.issued2019-
dc.identifier.issn2384-1095-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175199-
dc.description.abstractPurpose: To investigate noninvasive biomarkers for predicting treatment response in patients with locally advanced HCC who underwent concurrent chemoradiotherapy (CCRTx). Materials and Methods: Thirty patients (55.5 ± 10.2 years old, M:F = 24:6) who underwent CCRTx due to advanced HCC were enrolled. Contrast-enhanced US (CEUS) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) were obtained before and immediately after CCRTx. The third CEUS was obtained at one month after CCRTx was completed. Response was assessed at three months after CCRTx based on RECIST 1.1. Quantitative imaging biomarkers measured with CEUS and MRI were compared between groups. A cutoff value was calculated with ROC analysis. Overall survival (OS) was compared by the Breslow method. Results: Twenty-five patients were categorized into the non-progression group and five patients were categorized into the progression group. Peak enhancement of the first CEUS before CCRTx (PE1) was significantly lower in the non-progression group (median, 18.6%; IQR, 20.9%) than that in the progression group (median, 59.1%; IQR, 13.5%; P = 0.002). There was no significant difference in other quantitative biomarkers between the two groups. On ROC analysis, with a cutoff value of 42.6% in PE1, the non-progression group was diagnosed with a sensitivity of 90.9% and a specificity of 100%. OS was also significantly longer in patients with PE1 < 42.6% (P = 0.014). Conclusion: Early treatment response and OS could be predicted by PE on CEUS before CCRTx in patients with HCC.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society of Magnetic Resonance in Medicine-
dc.relation.isPartOfInvestigative Magnetic Resonance Imaging-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleNoninvasive Biomarker for Predicting Treatment Response to Concurrent Chemoradiotherapy in Patients with Hepatocellular Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorJin-Young Choi-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.contributor.googleauthorMi-suk Park-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.13104/imri.2019.23.4.351-
dc.contributor.localIdA00426-
dc.contributor.localIdA01463-
dc.contributor.localIdA01463-
dc.contributor.localIdA01675-
dc.contributor.localIdA01675-
dc.contributor.localIdA01956-
dc.contributor.localIdA01956-
dc.contributor.localIdA03662-
dc.contributor.localIdA03662-
dc.contributor.localIdA04200-
dc.contributor.localIdA04200-
dc.relation.journalcodeJ01186-
dc.identifier.eissn2384-1109-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordUltrasonography-
dc.subject.keywordPerfusion imaging-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordChemoradiotherapy-
dc.subject.keywordBiomarkers-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.affiliatedAuthor김명진-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor성진실-
dc.contributor.affiliatedAuthor성진실-
dc.contributor.affiliatedAuthor정용은-
dc.contributor.affiliatedAuthor정용은-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor최진영-
dc.citation.volume23-
dc.citation.number4-
dc.citation.startPage351-
dc.citation.endPage360-
dc.identifier.bibliographicCitationInvestigative Magnetic Resonance Imaging, Vol.23(4) : 351-360, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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