The effect of administration of parathyroid hormone (1-34) on sinus bone graft & dental implant in ovariectomized rabbits

Abstract

Purpose: The purpose of the present study is to investigate the effect of administering intermittent parathyroid hormone[Teriparatide , PTH (1-34)], on the maxillary sinus lift and bone graft in osteoporosis-induced rabbits. Materials and Methods: Twenty female New Zealand white rabbits were received ovariectomy. The animals were randomly divided into two groups: PTH group (n =10); 10 g/kg/day PTH was injected subcutaneously 5 days a week for 5 weeks (1 week before, 4 weeks after sinus surgery). Saline group (n=10); same dose and duration of saline was injected. In maxillary sinus surgery, bone graft with Bio-oss® was augmented into 13 sinuses, and bone grafts and implants were simultaneously performed in 7 sinuses. Animals were sacrificed 4 weeks after surgery. To determine whether PTH was effective for osteoporosis, we measured the BMD of the right femur using microCT, and performed radiographic and histometric analysis of the maxillary sinus surgery site. Statistics used Mann-Whitney test. Result: BMD increased in the femur, but in sinus, all parameters of radiographic and histometric analysis showed no significant difference between the groups, and the difference between individuals was even greater. Conclusion: Intermittent PTH might not promote new bone formation in the augmented maxillary sinus of ovariectomized rabbits.