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Effect of Cognitive Reserve on Risk of Cognitive Impairment and Recovery After Stroke: The KOSCO Study

Authors
 Minyoung Shin  ;  Min Kyun Sohn  ;  Jongmin Lee  ;  Deog Young Kim  ;  Sam-Gyu Lee  ;  Yong-Il Shin  ;  Gyung-Jae Oh  ;  Yang-Soo Lee  ;  Min Cheol Joo  ;  Eun Young Han  ;  Junhee Han  ;  Jeonghoon Ahn  ;  Won Hyuk Chang  ;  Min A Shin  ;  Ji Yoo Choi  ;  Sung Hyun Kang  ;  Youngtaek Kim  ;  Yun-Hee Kim 
Citation
 STROKE, Vol.51(1) : 99-107, 2020 
Journal Title
 STROKE 
ISSN
 0039-2499 
Issue Date
2020
Keywords
cognitive dysfunction ; cognitive reserve ; education ; longitudinal studies ; occupation ; risk factors ; stroke
Abstract
Background and Purpose- The theory of cognitive reserve (CR) was introduced to account for individual differences in the clinical manifestation of neuropathology. This study investigated whether CR has a modulating effect on cognitive impairment and recovery after stroke. Methods- This study is an interim analysis of the Korean Stroke Cohort for Functioning and Rehabilitation. A total of 7459 patients with first-ever stroke were included for analysis. Education, occupation, and composite CR scores derived from those 2 variables were used as CR proxies. Scores from the Korean version of the Mini-Mental State Examination analyzed for 30 months after stroke onset were analyzed. Results- Lower CR increased the risk of cognitive impairment after stroke. The odds ratio was 1.89 (95% CI, 1.64-2.19) in patients with secondary education and 2.42 (95% CI, 2.03-2.90) in patients with primary education compared with patients with higher education. The odds ratio was 1.48 (95% CI, 1.23-1.98) in patients with a skilled manual occupation and 2.01 (95% CI, 1.42-2.83) in patients with a nonskilled manual occupation compared with patients with a managerial or professional occupation. In the multilevel model analysis, the Korean version of the Mini-Mental State Examination total score increased during the first 3 months (1.93 points per month) and then plateaued (0.02 point per month). The slopes were moderated by the level of education, occupation, and composite CR score: the higher the level of education, occupation, or CR score, the faster the recovery. In the older adult group, the Korean version of the Mini-Mental State Examination scores showed a long-term decline that was moderated by education level. Conclusions- Education and occupation can buffer an individual against cognitive impairment caused by stroke and promote rapid cognitive recovery early after stroke. In addition, higher education minimizes long-term cognitive decline after stroke, especially in older patients. Clinical Trial Registration- URL: https://www.clinicaltrials.gov. Unique identifier: NCT03402451.
Files in This Item:
T202000166.pdf Download
DOI
10.1161/STROKEAHA.119.026829
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deog Young(김덕용) ORCID logo https://orcid.org/0000-0001-7622-6311
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174925
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