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Neural correlates and gait characteristics for hypoxic-ischemic brain injury induced freezing of gait

Authors
 Seo Yeon Yoon  ;  Sang Chul Lee  ;  Young-sil An  ;  Yong Wook Kim 
Citation
 CLINICAL NEUROPHYSIOLOGY, Vol.131(1) : 46-53, 2020 
Journal Title
 CLINICAL NEUROPHYSIOLOGY 
ISSN
 1388-2457 
Issue Date
2020
Keywords
Brain metabolism ; Freezing of gait ; Gait analysis ; Hypoxic-ischemic brain injury
Abstract
OBJECTIVE: To investigate gait characteristics in patients with freezing of gait (FOG) after hypoxic-ischemic brain injury (HIBI) and to elucidate neural correlates for FOG using F-18 fluoro-2-deoxy-d-glucose positron emission tomography. METHODS: We enrolled 12 patients with FOG after HIBI and 17 patients without FOG after HIBI. We performed three-dimensional gait analyses and compared each parameter and gait variability. Brain metabolism was measured, and we compared regional brain metabolism using a voxel-by-voxel-based statistical mapping analysis. RESULTS: The FOG group revealed a significantly decreased joint range of motion (ROM), particularly in the sagittal plane for three-joint summated ROM (p < 0.0025). Spatiotemporal results demonstrated that stride length and step length were decreased in the with FOG group (p < 0.005). FOG severity was negatively correlated with brain metabolism in the left thalamus, and three-joint summated ROM in the sagittal plane was positively associated with brain metabolism in the left thalamus and midbrain (p < 0.05). CONCLUSIONS: Central organizational level amplitude disorder may play an important role in the pathophysiology, and disturbance in the cholinergic pathway might contribute to the development of FOG in patients with HIBI. SIGNIFICANCE: These findings contribute to understanding FOG in HIBI.
Full Text
https://www.sciencedirect.com/science/article/pii/S1388245719312635
DOI
10.1016/j.clinph.2019.09.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Lee, Sang Chul(이상철) ORCID logo https://orcid.org/0000-0002-6241-7392
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174912
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