78 114

Cited 1 times in

Autophagy, Cellular Aging and Age-related Human Diseases

Authors
 So Yeong Cheon  ;  Hyunjeong Kim  ;  David C. Rubinsztein  ;  Jong Eun Lee 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.28(6) : 643-657, 2019 
Journal Title
 EXPERIMENTAL NEUROBIOLOGY 
ISSN
 1226-2560 
Issue Date
2019
Keywords
Aging ; Autophagy ; DNA damage ; Oxidative stress ; SASP ; Telomere shortening
Abstract
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with progressively compromised autophagy. Dysfunctional autophagy may contribute to age-related diseases, such as neurodegenerative disease, cancer, and metabolic syndrome, in the elderly. Therefore, restoration of impaired autophagy to normal may help to prevent age-related disease and extend lifespan and longevity. Therefore, this review aims to provide an overview of the mechanisms of autophagy underlying cellular aging and the consequent disease. Understanding the mechanisms of autophagy may provide potential information to aid therapeutic interventions in age-related diseases.
Files in This Item:
T201905607.pdf Download
DOI
10.5607/en.2019.28.6.643
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174782
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links