53 79

Cited 0 times in

Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study

Authors
 Christina Jeon  ;  Ji-Young Lee  ;  Sun Ju Lee  ;  Keum Ji Jung  ;  Heejin Kimm  ;  Sun Ha Jee 
Citation
 EPIDEMIOLOGY AND HEALTH, Vol.41 : e2019034, 2019 
Journal Title
 EPIDEMIOLOGY AND HEALTH 
Issue Date
2019
Keywords
Bilirubin ; Korea ; Myocardial ischemia ; Two-sample Mendelian randomization study
Abstract
OBJECTIVES: Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in previous studies. Nonetheless, whether those associations reflect a true protective effect of bilirubin on IHD, rather than confounding or reverse causation, remains unknown. Therefore, we applied two-sample Mendelian randomization to evaluate the causal association between bilirubin levels and IHD risk in a Korean population. METHODS: A total of 5 genetic variants-TRPM8 (rs10490012), USP40 (rs12993249), ATG16L1 (rs2119503), SLCO1B1 (rs4149014), and SLCO1B3 (rs73233620)-were selected as genetic instruments for serum bilirubin levels using a communitybased cohort, the Korean Genome and Epidemiology Study, comprising 33,598 subjects. We then evaluated their impact on IHD using the Korean Cancer Prevention Study-II cohort. RESULTS: Among the 5 instrumental variables that showed significant associations with serum bilirubin levels, rs12993249 (USP40) showed the most significant association (p<2.36×10-105). However, we found no significant association between serum bilirubin levels and IHD. Sensitivity analyses demonstrated a consistent association, suggesting that our observations were robust. CONCLUSIONS: Using two-sample Mendelian randomization, we found no association between serum bilirubin levels and IHD. Further studies that confirm the observed interactions among other ethnicities are warranted.
Files in This Item:
T201905484.pdf Download
DOI
10.4178/epih.e2019034
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Lee, Sun Ju(이선주) ORCID logo https://orcid.org/0000-0002-6582-8795
Lee, Ji Young(이지영) ORCID logo https://orcid.org/0000-0002-7784-1401
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174753
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links