Cited 8 times in
Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study
DC Field | Value | Language |
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dc.contributor.author | 김희진 | - |
dc.contributor.author | 이지영 | - |
dc.contributor.author | 정금지 | - |
dc.contributor.author | 지선하 | - |
dc.contributor.author | 이선주 | - |
dc.date.accessioned | 2020-02-11T06:37:19Z | - |
dc.date.available | 2020-02-11T06:37:19Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174753 | - |
dc.description.abstract | OBJECTIVES: Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in previous studies. Nonetheless, whether those associations reflect a true protective effect of bilirubin on IHD, rather than confounding or reverse causation, remains unknown. Therefore, we applied two-sample Mendelian randomization to evaluate the causal association between bilirubin levels and IHD risk in a Korean population. METHODS: A total of 5 genetic variants-TRPM8 (rs10490012), USP40 (rs12993249), ATG16L1 (rs2119503), SLCO1B1 (rs4149014), and SLCO1B3 (rs73233620)-were selected as genetic instruments for serum bilirubin levels using a communitybased cohort, the Korean Genome and Epidemiology Study, comprising 33,598 subjects. We then evaluated their impact on IHD using the Korean Cancer Prevention Study-II cohort. RESULTS: Among the 5 instrumental variables that showed significant associations with serum bilirubin levels, rs12993249 (USP40) showed the most significant association (p<2.36×10-105). However, we found no significant association between serum bilirubin levels and IHD. Sensitivity analyses demonstrated a consistent association, suggesting that our observations were robust. CONCLUSIONS: Using two-sample Mendelian randomization, we found no association between serum bilirubin levels and IHD. Further studies that confirm the observed interactions among other ethnicities are warranted. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | EPIDEMIOLOGY AND HEALTH | - |
dc.publisher | EPIDEMIOLOGY AND HEALTH | - |
dc.relation.isPartOf | EPIDEMIOLOGY AND HEALTH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Christina Jeon | - |
dc.contributor.googleauthor | Ji-Young Lee | - |
dc.contributor.googleauthor | Sun Ju Lee | - |
dc.contributor.googleauthor | Keum Ji Jung | - |
dc.contributor.googleauthor | Heejin Kimm | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.identifier.doi | 10.4178/epih.e2019034 | - |
dc.contributor.localId | A01226 | - |
dc.contributor.localId | A03201 | - |
dc.contributor.localId | A03580 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00791 | - |
dc.identifier.eissn | 2092-7193 | - |
dc.identifier.pmid | 31319653 | - |
dc.subject.keyword | Bilirubin | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Myocardial ischemia | - |
dc.subject.keyword | Two-sample Mendelian randomization study | - |
dc.contributor.alternativeName | Kimm, Hee Jin | - |
dc.contributor.affiliatedAuthor | 김희진 | - |
dc.contributor.affiliatedAuthor | 이지영 | - |
dc.contributor.affiliatedAuthor | 정금지 | - |
dc.contributor.affiliatedAuthor | 지선하 | - |
dc.citation.volume | 41 | - |
dc.citation.startPage | e2019034 | - |
dc.identifier.bibliographicCitation | EPIDEMIOLOGY AND HEALTH, Vol.41 : e2019034, 2019 | - |
dc.identifier.rimsid | 64051 | - |
dc.type.rims | ART | - |
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