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Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

Authors
 SeonJu Park  ;  Youn Hee Nam  ;  Isabel Rodriguez  ;  Jun Hyung Park  ;  Hee Jae Kwak  ;  Youngse Oh  ;  Mira Oh  ;  Min Seon Park  ;  Kye Wan Lee  ;  Jung Suk Lee  ;  Do Hoon Kim  ;  Yu Hwa Park  ;  In Seok Moon  ;  Se-Young Choung  ;  Kwang Won Jeong  ;  Bin Na Hong  ;  Tong Ho Kang  ;  Seung Hyun Kim 
Citation
 REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, Vol.29(6) : 739-743, 2019 
Journal Title
 REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY 
ISSN
 0102-695X 
Issue Date
2019
Keywords
Lauraceae ; Flavonol glycoside ; Megastigmane glycosides ; Lignans
Abstract
Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (2–11), four megastigmane glycosides (12–15) and two lignans (16–17) were isolated. Their structures were determined by extensive spectroscopic methods including 1D- and 2D-nuclear magnetic resonance and mass spectrometry data. This is the first investigation that reports megastigmane glycoside and lignan classes within the genus Persea. All the isolated compounds have been assessed through the cell survival of larval zebrafish following neomycin-induced damage and the cell viability of a House Ear Institute-Organ of Corti 1 mouse auditory cell line. Among the tested compounds, juglanin (2) and (+)-lyoniresinol (16) showed significant cell regeneration in neomycin-damaged hair cell without cellular toxicity.
Full Text
https://www.sciencedirect.com/science/article/pii/S0102695X19302832#!
DOI
10.1016/j.bjp.2019.08.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174705
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