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Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

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dc.contributor.author문인석-
dc.date.accessioned2020-02-11T06:30:37Z-
dc.date.available2020-02-11T06:30:37Z-
dc.date.issued2019-
dc.identifier.issn0102-695X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174705-
dc.description.abstractPersea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (2–11), four megastigmane glycosides (12–15) and two lignans (16–17) were isolated. Their structures were determined by extensive spectroscopic methods including 1D- and 2D-nuclear magnetic resonance and mass spectrometry data. This is the first investigation that reports megastigmane glycoside and lignan classes within the genus Persea. All the isolated compounds have been assessed through the cell survival of larval zebrafish following neomycin-induced damage and the cell viability of a House Ear Institute-Organ of Corti 1 mouse auditory cell line. Among the tested compounds, juglanin (2) and (+)-lyoniresinol (16) showed significant cell regeneration in neomycin-damaged hair cell without cellular toxicity.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSociedade Brasileira de Farmacognosia-
dc.relation.isPartOfREVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleChemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학교실)-
dc.contributor.googleauthorSeonJu Park-
dc.contributor.googleauthorYoun Hee Nam-
dc.contributor.googleauthorIsabel Rodriguez-
dc.contributor.googleauthorJun Hyung Park-
dc.contributor.googleauthorHee Jae Kwak-
dc.contributor.googleauthorYoungse Oh-
dc.contributor.googleauthorMira Oh-
dc.contributor.googleauthorMin Seon Park-
dc.contributor.googleauthorKye Wan Lee-
dc.contributor.googleauthorJung Suk Lee-
dc.contributor.googleauthorDo Hoon Kim-
dc.contributor.googleauthorYu Hwa Park-
dc.contributor.googleauthorIn Seok Moon-
dc.contributor.googleauthorSe-Young Choung-
dc.contributor.googleauthorKwang Won Jeong-
dc.contributor.googleauthorBin Na Hong-
dc.contributor.googleauthorTong Ho Kang-
dc.contributor.googleauthorSeung Hyun Kim-
dc.identifier.doi10.1016/j.bjp.2019.08.004-
dc.contributor.localIdA01374-
dc.relation.journalcodeJ03771-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0102695X19302832#!-
dc.subject.keywordLauraceae-
dc.subject.keywordFlavonol glycoside-
dc.subject.keywordMegastigmane glycosides-
dc.subject.keywordLignans-
dc.contributor.alternativeNameMoon, In Seok-
dc.contributor.affiliatedAuthor문인석-
dc.citation.volume29-
dc.citation.number6-
dc.citation.startPage739-
dc.citation.endPage743-
dc.identifier.bibliographicCitationREVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, Vol.29(6) : 739-743, 2019-
dc.identifier.rimsid63559-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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