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Clinical utility of mono-exponential model diffusion weighted imaging using two b-values compared to the bi- or stretched exponential model for the diagnosis of biliary atresia in infant liver MRI
DC Field | Value | Language |
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dc.contributor.author | 고홍 | - |
dc.contributor.author | 김명준 | - |
dc.contributor.author | 김승 | - |
dc.contributor.author | 신현주 | - |
dc.contributor.author | 윤혜성 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 한경화 | - |
dc.contributor.author | 한석주 | - |
dc.date.accessioned | 2020-02-11T06:29:29Z | - |
dc.date.available | 2020-02-11T06:29:29Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174696 | - |
dc.description.abstract | PURPOSE: To investigate the clinical utility of mono-exponential model diffusion weighted imaging (DWI) using two b-values compared to the bi- or stretched exponential model to differentiate biliary atresia (BA) from non-BA in pediatric liver magnetic resonance imaging (MRI). METHODS: Patients who underwent liver MRI with DWI for suspected BA from November 2017 to September 2018 were retrospectively included and divided into BA and non-BA groups. Laboratory results including γ-glutamyl transferase (γGT) were compared between the two groups using the Mann-Whitney U test and Fisher's exact test. The hepatic apparent diffusion coefficient (ADC) 10 using ten b-values and ADC 2 using two b-values were obtained from the mono-exponential model. The slow diffusion coefficient (D), fast diffusion coefficient (D*), and perfusion fraction (f) were obtained from the bi-exponential model. The distributed diffusion coefficient (DDC) and heterogeneity index (α) were measured from the stretched exponential model. Parameters were compared between the two groups using a linear mixed model and diagnostic performance was assessed using the area under the curve (AUC) analysis. RESULTS: For 12 patients in the BA and five patients in the non-BA group, the ADC 10 (median 0.985 ×10-3 mm2/s vs. 1.332 ×10-3 mm2/s, p = 0.008), ADC 2 (median 0.987 ×10-3 mm2/s vs. 1.335 ×10-3 mm2/s, p = 0.017), D* (median 33.2 ×10-3 mm2/s vs. 55.3 ×10-3 mm2/s, p = 0.021), f (median 13.4%, vs. 22.1%, p = 0.009), and DDC (median 0.889 ×10-3 mm2/s vs. 1.323 ×10-3 mm2/s, p = 0.009) values were lower and the γGT (median 368.0 IU/L vs. 93.5 IU/L, p = 0.02) and α (median 0.699 vs. 0.556, p = 0.023) values were higher in the BA group. The AUC values for γGT (AUC 0.867 95% confidence interval [CI] 0.616-0.984), ADC 10 (AUC 0.963, 95% CI 0.834-0.998), ADC 2 (AUC 0.925, 95% CI 0.781-0.987), f (AUC 0.850, 95% CI 0.686-0.949), and DDC (AUC 0.925, 95% CI 0.781-0.987) were not significantly different, except for the D* and α values. CONCLUSION: Patients with BA had lower ADC 10, ADC 2, D*, f, and DDC values and higher γGT and α values than those in the non-BA group. The diagnostic performance of ADC 2 using only two b-values showed excellent diagnostic performance and was not significantly different from that of γGT, ADC 10, f, and DDC for diagnosing BA. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical utility of mono-exponential model diffusion weighted imaging using two b-values compared to the bi- or stretched exponential model for the diagnosis of biliary atresia in infant liver MRI | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Jisoo Kim | - |
dc.contributor.googleauthor | Haesung Yoon | - |
dc.contributor.googleauthor | Mi-Jung Lee | - |
dc.contributor.googleauthor | Myung-Joon Kim | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Seok Joo Han | - |
dc.contributor.googleauthor | Hong Koh | - |
dc.contributor.googleauthor | Seung Kim | - |
dc.contributor.googleauthor | Hyun Joo Shin | - |
dc.identifier.doi | 10.1371/journal.pone.0226627 | - |
dc.contributor.localId | A00156 | - |
dc.contributor.localId | A00425 | - |
dc.contributor.localId | A00651 | - |
dc.contributor.localId | A02178 | - |
dc.contributor.localId | A04989 | - |
dc.contributor.localId | A02774 | - |
dc.contributor.localId | A04267 | - |
dc.contributor.localId | A04288 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 31852012 | - |
dc.contributor.alternativeName | Koh, Hong | - |
dc.contributor.affiliatedAuthor | 고홍 | - |
dc.contributor.affiliatedAuthor | 김명준 | - |
dc.contributor.affiliatedAuthor | 김승 | - |
dc.contributor.affiliatedAuthor | 신현주 | - |
dc.contributor.affiliatedAuthor | 윤혜성 | - |
dc.contributor.affiliatedAuthor | 이미정 | - |
dc.contributor.affiliatedAuthor | 한경화 | - |
dc.contributor.affiliatedAuthor | 한석주 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e0226627 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.14(12) : e0226627, 2019 | - |
dc.identifier.rimsid | 64480 | - |
dc.type.rims | ART | - |
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