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Clinical utility of mono-exponential model diffusion weighted imaging using two b-values compared to the bi- or stretched exponential model for the diagnosis of biliary atresia in infant liver MRI

DC FieldValueLanguage
dc.contributor.author고홍-
dc.contributor.author김명준-
dc.contributor.author김승-
dc.contributor.author신현주-
dc.contributor.author윤혜성-
dc.contributor.author이미정-
dc.contributor.author한경화-
dc.contributor.author한석주-
dc.date.accessioned2020-02-11T06:29:29Z-
dc.date.available2020-02-11T06:29:29Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174696-
dc.description.abstractPURPOSE: To investigate the clinical utility of mono-exponential model diffusion weighted imaging (DWI) using two b-values compared to the bi- or stretched exponential model to differentiate biliary atresia (BA) from non-BA in pediatric liver magnetic resonance imaging (MRI). METHODS: Patients who underwent liver MRI with DWI for suspected BA from November 2017 to September 2018 were retrospectively included and divided into BA and non-BA groups. Laboratory results including γ-glutamyl transferase (γGT) were compared between the two groups using the Mann-Whitney U test and Fisher's exact test. The hepatic apparent diffusion coefficient (ADC) 10 using ten b-values and ADC 2 using two b-values were obtained from the mono-exponential model. The slow diffusion coefficient (D), fast diffusion coefficient (D*), and perfusion fraction (f) were obtained from the bi-exponential model. The distributed diffusion coefficient (DDC) and heterogeneity index (α) were measured from the stretched exponential model. Parameters were compared between the two groups using a linear mixed model and diagnostic performance was assessed using the area under the curve (AUC) analysis. RESULTS: For 12 patients in the BA and five patients in the non-BA group, the ADC 10 (median 0.985 ×10-3 mm2/s vs. 1.332 ×10-3 mm2/s, p = 0.008), ADC 2 (median 0.987 ×10-3 mm2/s vs. 1.335 ×10-3 mm2/s, p = 0.017), D* (median 33.2 ×10-3 mm2/s vs. 55.3 ×10-3 mm2/s, p = 0.021), f (median 13.4%, vs. 22.1%, p = 0.009), and DDC (median 0.889 ×10-3 mm2/s vs. 1.323 ×10-3 mm2/s, p = 0.009) values were lower and the γGT (median 368.0 IU/L vs. 93.5 IU/L, p = 0.02) and α (median 0.699 vs. 0.556, p = 0.023) values were higher in the BA group. The AUC values for γGT (AUC 0.867 95% confidence interval [CI] 0.616-0.984), ADC 10 (AUC 0.963, 95% CI 0.834-0.998), ADC 2 (AUC 0.925, 95% CI 0.781-0.987), f (AUC 0.850, 95% CI 0.686-0.949), and DDC (AUC 0.925, 95% CI 0.781-0.987) were not significantly different, except for the D* and α values. CONCLUSION: Patients with BA had lower ADC 10, ADC 2, D*, f, and DDC values and higher γGT and α values than those in the non-BA group. The diagnostic performance of ADC 2 using only two b-values showed excellent diagnostic performance and was not significantly different from that of γGT, ADC 10, f, and DDC for diagnosing BA.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical utility of mono-exponential model diffusion weighted imaging using two b-values compared to the bi- or stretched exponential model for the diagnosis of biliary atresia in infant liver MRI-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorJisoo Kim-
dc.contributor.googleauthorHaesung Yoon-
dc.contributor.googleauthorMi-Jung Lee-
dc.contributor.googleauthorMyung-Joon Kim-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorSeok Joo Han-
dc.contributor.googleauthorHong Koh-
dc.contributor.googleauthorSeung Kim-
dc.contributor.googleauthorHyun Joo Shin-
dc.identifier.doi10.1371/journal.pone.0226627-
dc.contributor.localIdA00156-
dc.contributor.localIdA00425-
dc.contributor.localIdA00425-
dc.contributor.localIdA00651-
dc.contributor.localIdA00651-
dc.contributor.localIdA02178-
dc.contributor.localIdA02178-
dc.contributor.localIdA04989-
dc.contributor.localIdA04989-
dc.contributor.localIdA02774-
dc.contributor.localIdA02774-
dc.contributor.localIdA04267-
dc.contributor.localIdA04267-
dc.contributor.localIdA04288-
dc.contributor.localIdA04288-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid31852012-
dc.contributor.alternativeNameKoh, Hong-
dc.contributor.affiliatedAuthor고홍-
dc.contributor.affiliatedAuthor김명준-
dc.contributor.affiliatedAuthor김명준-
dc.contributor.affiliatedAuthor김승-
dc.contributor.affiliatedAuthor김승-
dc.contributor.affiliatedAuthor신현주-
dc.contributor.affiliatedAuthor신현주-
dc.contributor.affiliatedAuthor윤혜성-
dc.contributor.affiliatedAuthor윤혜성-
dc.contributor.affiliatedAuthor이미정-
dc.contributor.affiliatedAuthor이미정-
dc.contributor.affiliatedAuthor한경화-
dc.contributor.affiliatedAuthor한경화-
dc.contributor.affiliatedAuthor한석주-
dc.contributor.affiliatedAuthor한석주-
dc.citation.volume14-
dc.citation.number12-
dc.citation.startPagee0226627-
dc.identifier.bibliographicCitationPLOS ONE, Vol.14(12) : e0226627, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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