19 38

Cited 0 times in

Regional Connectivity Changes According to Seizure Outcome of Temporal Epilepsy Surgery- A Magnetoencephalography Study

 Kyoo Ho Cho  ;  Su Jung Hwang  ;  Bong Soo Kim  ;  Kyoung Heo  ;  Won Seok Chang  ;  Jin Woo Chang 
 Biomedical Journal of Scientific & Technical Research, Vol.22(3) : 16657-16665, 2019 
Journal Title
 Biomedical Journal of Scientific & Technical Research 
Issue Date
Epilepsy ; Magnetoencephalography ; Prognosis ; Temporal lobectomy ; Connectivity
Objective: Temporal lobectomy is often successful in treatment of patients with medically intractable temporal lobe epilepsy (TLE), but prediction of its long-term outcome is of great interest. Here, we investigated usefulness of comparison analysis of pre- and post-surgical magnetoencephalopgrahy data in predicting prognosis of temporal lobectomy. Methods: The authors retrospectively analyzed pre-and post-operative MEG and presence of any seizures after temporal lobectomy in 8 patients with TLE. Spectral powers averaged from spike-free epochs in each condition (pre- and post-operation) were compared between 4 patients free from seizures and the other 4 with recurrent seizures. We also performed connectivity analysis based on phase locking values (PLVs) around resection margins of possible epileptogenic focus as regions of interest. Results: Spectral analysis on peri-lesional areas demonstrated relative increase of delta power in the patients without seizure freedom. On connectivity analysis, decrease of PLVs between other areas and temporal lobe focus after surgery were noted in patients with good surgical outcome while persistence or increase were found in patients with recurred seizures. Conclusion: This pilot study on comparison of power spectrum and connectivity metrics between pre- and post-op MEG exhibits a potential for predicting seizure outcome after TLE surgery.
Files in This Item:
T201905247.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Bong Soo(김봉수)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Cho, Kyoo Ho(조규호) ORCID logo https://orcid.org/0000-0003-2402-7198
Heo, Kyoung(허경)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.