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Regenerative effects of mesenchymal stem cells by dosage in a chronic rotator cuff tendon tear in a rabbit model

Authors
 Dong Rak Kwon  ;  Gi-Young Park  ;  Sang Chul Lee 
Citation
 REGENERATIVE MEDICINE, Vol.14(11) : 1001-1012, 2019 
Journal Title
 REGENERATIVE MEDICINE 
ISSN
 1746-0751 
Issue Date
2019
Keywords
dose-response relationship ; injections ; mesenchymal stem cells ; rabbits ; regeneration ; rotator cuff ; shoulder ; tendons ; ultrasonography ; umblical cord
Abstract
Aim: We investigated the therapeutic effects and optimal dose of human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection in a chronic full-thickness rotator cuff tendon tear. Methods: Rabbits (n = 30) were allocated into three groups (normal saline, G1-Sal; 1 × 106 cells UCB-MSC, G2-Low; 2 × 106 cells UCB-MSC, G3-High). Injections were done into the chronic full-thickness rotator cuff tendon tear 6 weeks after a full-thickness tendon tear of the subscapularis was created. Gross & histologic evaluation and motion analysis was done at pre and 4 weeks post-injection. Results: There were no significant differences in tear size and motion analysis parameters 4 weeks after injection between G2-Low and G3-High. Conclusion: The benefits of UCB-MSCs are not dose-dependent in a rabbit model.
DOI
10.2217/rme-2018-0125
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Chul(이상철) ORCID logo https://orcid.org/0000-0002-6241-7392
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174639
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