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Periodontal healing using a collagen matrix with periodontal ligament progenitor cells in a dehiscence defect model in beagle dogs

DC FieldValueLanguage
dc.contributor.author김슬기-
dc.contributor.author김창성-
dc.contributor.author이중석-
dc.contributor.author차재국-
dc.date.accessioned2020-02-11T06:13:28Z-
dc.date.available2020-02-11T06:13:28Z-
dc.date.issued2019-
dc.identifier.issn2093-2278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174592-
dc.description.abstractPurpose: To histologically characterize periodontal healing at 8 weeks in surgically created dehiscence defects in beagle dogs that received a collagen matrix with periodontal ligament (PDL) progenitor cells. Methods: The bilateral maxillary premolars and first molars in 6 animals were used. Standardized experimental dehiscence defects were made on the buccal side of 3 premolars, and primary culturing of PDL progenitor cells was performed on the molars. Collagen matrix was used as a scaffold and a delivery system for PDL progenitor cells. The experimental sites were grafted with collagen matrix (COL), PDL progenitor cells with collagen matrix (COL/CELL), or left without any material (CTL). Histologic and histomorphometric analyses were performed after 8 weeks. Results: The defect height from the cementoenamel junction to the most apical point of cementum removal did not significantly differ across the CTL, COL, and COL/CELL groups, at 4.57±0.28, 4.56±0.41, and 4.64±0.27 mm (mean ± standard deviation), respectively; the corresponding values for epithelial adhesion were 1.41±0.51, 0.85±0.29, and 0.30±0.41 mm (P<0.05), the heights of new bone regeneration were 1.32±0.44, 1.65±0.52, and 1.93±0.61 mm (P<0.05), and the cementum regeneration values were 1.15±0.42, 1.81±0.46, and 2.57±0.56 mm (P<0.05). There was significantly more new bone formation in the COL/CELL group than in the CTL group, and new cementum length was also significantly higher in the COL/CELL group. However, there were no significant differences in the width of new cementum among the groups. Conclusions: PDL progenitor cells carried by a synthetic collagen matrix may enhance periodontal regeneration, including cementum and new bone formation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Academy of Periodontology-
dc.relation.isPartOfJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePeriodontal healing using a collagen matrix with periodontal ligament progenitor cells in a dehiscence defect model in beagle dogs-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorSeung-Yoon Yoo-
dc.contributor.googleauthorJung-Seok Lee-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorSeul-Ki Kim-
dc.contributor.googleauthorChang-Sung Kim-
dc.identifier.doi10.5051/jpis.2019.49.4.215-
dc.contributor.localIdA05820-
dc.contributor.localIdA01041-
dc.contributor.localIdA01041-
dc.contributor.localIdA03185-
dc.contributor.localIdA03185-
dc.contributor.localIdA04004-
dc.contributor.localIdA04004-
dc.relation.journalcodeJ01695-
dc.identifier.eissn2093-2286-
dc.identifier.pmid31485372-
dc.subject.keywordCollagen matrix-
dc.subject.keywordDehiscence defect-
dc.subject.keywordPeriodontal ligament progenitor cells-
dc.subject.keywordPeriodontal regeneration-
dc.contributor.alternativeNameKim, Seul-Ki-
dc.contributor.affiliatedAuthor김슬기-
dc.contributor.affiliatedAuthor김창성-
dc.contributor.affiliatedAuthor김창성-
dc.contributor.affiliatedAuthor이중석-
dc.contributor.affiliatedAuthor이중석-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor차재국-
dc.citation.volume49-
dc.citation.number4-
dc.citation.startPage215-
dc.citation.endPage227-
dc.identifier.bibliographicCitationJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.49(4) : 215-227, 2019-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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