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Cited 3 times in

Intradermal Testing With Radiocontrast Media to Prevent Recurrent Adverse Reactions

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dc.contributor.author김성렬-
dc.contributor.author박경희-
dc.contributor.author박중원-
dc.contributor.author오영택-
dc.contributor.author이재현-
dc.contributor.author홍유진-
dc.date.accessioned2020-02-11T06:10:49Z-
dc.date.available2020-02-11T06:10:49Z-
dc.date.issued2019-
dc.identifier.issn0361-803X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174572-
dc.description.abstractOBJECTIVE. Adverse drug reactions (ADRs) to radiocontrast media are a significant social and economic burden and are difficult to predict. Because some ADRs to radiocontrast media may be immunologically induced, a skin test with diluted 1:10 radiocontrast media has been used to predict ADRs. However, using this test in clinical practice is difficult because of its low sensitivity. SUBJECTS AND METHODS. This study enrolled 36 patients with a history of immediate ADR to radiocontrast media who visited the Allergy and Asthma Clinic of Severance Hospital from 2017 to 2018. Patients underwent intradermal testing (IDT) with five types of diluted (1:10) and undiluted radiocontrast media (iohexol, iobitridol, iopamidol, iopromide, and iodixanol). The IDT result was regarded as positive if at least one radiocontrast medium elicited a positive reaction. Positivity of IDT and sensitivity to the culprit radiocontrast medium were calculated and compared. For subsequent CT examinations with a radiocontrast medium, the contrast agent eliciting a negative skin reaction in IDT was selected, excluding the previous culprit radiocontrast medium. RESULTS. IDT positivity and sensitivity for the culprit radiocontrast medium at 1:10 dilution were 47.2% and 47.2%, respectively, whereas the positivity and sensitivity for the undiluted radiocontrast medium were 86.1% and 75.0%, respectively. The positivity and sensitivity were higher with frequent radiocontrast medium use or with severe reaction. Of 22 patients who underwent another CT examination with the contrast medium selected on the basis of IDT results, 21 (95.5%) did not experience an ADR. CONCLUSION. IDT to prevent ADR should be performed with undiluted radiocontrast medium. Selecting an alternative radiocontrast agent on the basis of IDT results can be clinically useful to prevent recurrent ADRs to radiocontrast media.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringfield, Ill., Thomas-
dc.relation.isPartOfAMERICAN JOURNAL OF ROENTGENOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIntradermal Testing With Radiocontrast Media to Prevent Recurrent Adverse Reactions-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSung-Ryeol Kim-
dc.contributor.googleauthorKyung Hee Park-
dc.contributor.googleauthorYoo Jin Hong-
dc.contributor.googleauthorYoung Taik Oh-
dc.contributor.googleauthorJung-Won Park-
dc.contributor.googleauthorJae-Hyun Lee-
dc.identifier.doi10.2214/AJR.19.21547-
dc.contributor.localIdA00566-
dc.contributor.localIdA01427-
dc.contributor.localIdA01681-
dc.contributor.localIdA02390-
dc.contributor.localIdA03086-
dc.contributor.localIdA04422-
dc.relation.journalcodeJ00116-
dc.identifier.eissn1546-3141-
dc.identifier.pmid31414881-
dc.identifier.urlhttps://www.ajronline.org/doi/full/10.2214/AJR.19.21547-
dc.subject.keywordadverse drug reaction-
dc.subject.keywordintradermal tests-
dc.subject.keywordradiocontrast media-
dc.subject.keywordskin tests-
dc.contributor.alternativeNameKim, Sung Ryeol-
dc.contributor.affiliatedAuthor김성렬-
dc.contributor.affiliatedAuthor박경희-
dc.contributor.affiliatedAuthor박중원-
dc.contributor.affiliatedAuthor오영택-
dc.contributor.affiliatedAuthor이재현-
dc.contributor.affiliatedAuthor홍유진-
dc.citation.volume213-
dc.citation.number6-
dc.citation.startPage1187-
dc.citation.endPage1193-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF ROENTGENOLOGY, Vol.213(6) : 1187-1193, 2019-
dc.identifier.rimsid63498-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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