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The Relationship between Serum Alkaline Phosphatase and Arterial Stiffness in Korean Adults

Authors
 Jun-Hyuk Lee  ;  Ji-Won Lee  ;  Yong-Jae Lee 
Citation
 JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Vol.26(12) : 1084-1091, 2019 
Journal Title
 JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 
ISSN
 1340-3478 
Issue Date
2019
Keywords
Alkaline phosphatase ; Arterial stiffness ; Pulse wave velocity
Abstract
AIM: Serum alkaline phosphatase (ALP), a useful marker of hepatobiliary or bone disorders, has recently been found to be associated with cardiovascular diseases. This study aimed to examine the association of serum ALP level with arterial stiffness, as measured by brachial-ankle pulse wave velocity. METHODS: This cross-sectional study included 2476 participants (1486 men and 990 women) aged ≥ 20 years who underwent a medical examination. Pearson correlation analyses were conducted to examine the bivariate correlations between baPWV and clinical variables. To examine the independent relationship between serum ALP and baPWV, a multiple linear regression analysis was conducted with baPWV as the dependent variable in a sex-specific manner. RESULTS: After adjusting for age, body mass index, current smoking, alcohol drinking, regular exercise, hypertension, type 2 diabetes, dyslipidemia, chronic kidney disease, log-transformed AST, log-transformed ALT, and log-transformed GGT levels, log-transformed serum ALP level was positively and independently associated with baPWV (β=78.6 for men, P=0.001; and β=85.3 for women, P<0.001). CONCLUSIONS: Serum ALP level was positively and independently associated with baPWV in men and women, suggesting that an elevated ALP level may be a useful surrogate marker for arterial stiffness in adult men and women.
Files in This Item:
T201904354.pdf Download
DOI
10.5551/jat.48942
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Jun-Hyuk(이준혁) ORCID logo https://orcid.org/0000-0002-1007-1633
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174491
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