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HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions

Authors
 Sungkyoung Choi  ;  Sungyoung Lee  ;  Taesung Park 
Citation
 Genomics & Informatics, Vol.16(4) : e38, 2018 
Journal Title
 Genomics & Informatics 
ISSN
 1598-866X 
Issue Date
2018
Keywords
Gene-Gene interactions ; Generalized Structured Component Analysis ; Genome-wide association study ; Ridge regression
Abstract
Gene-gene interaction (GGI) analysis is known to play an important role in explain missing heritability issue. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in case-control design. In this study, we developed 'Hierarchical structural CoMponent analysis of Gene-Gene Interactions' (HisCoM-GGI) software for gene-gene interaction analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and SNPs, that enables both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various type of genomic data, and supports a data management and multithreading to improve the efficiency of GWAS data analysis. We expect that the HisCoM-GGI software provides advanced accessibility to the researchers on the genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.
Files in This Item:
T201806078.pdf Download
DOI
10.5808/GI.2018.16.4.e38
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Choi, Sungkyoung(최성경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174462
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