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정신분열병 환자에서 Haloperidol이 99m-Tc-ECD SPECT로 측정한 국소뇌혈류량에 미치는 영향

Other Titles
 The Effect of Haloperidol on Regional Cerebral Blood Flow Assessed with 99m-Tc-ECD SPECT in Schizophrenic Patients 
 천근아  ;  이종두  ;  민성길  ;  김세주  ;  안석균 
 Journal of the Korean Neuropsychiatric Association (신경정신의학), Vol.38(4) : 861-872, 1999 
Journal Title
 Journal of the Korean Neuropsychiatric Association (신경정신의학) 
Issue Date
Haloperidol ; 항정신병약물 비노출 ; 국소뇌혈류량 ; 뇌단일광자방출전산화 단층촬영 ; Schizophrenia ; Haloperidol ; Drug-naive Schizophrenic patients ; Regioal cerebral blood flow ; Single-photon emission computed tomography ; 정신분열병
Objectives : Regional cerebral blood flow(rCBF) in schizophrenics is confounded by various factors including medication status. Previously, there have been numerous studies regarding the effects of antipsychotics on rCBF. However, these works have shown contradictory and inconsistent findings due to the different of type, dose and exposed duration of antipsychotics. The aim of this study was to observe the effect of antipsychotic medication on rCBF and exposed duration of antipsychotics under control. Methods : Eighteen drug-naive schizophrenics and 19 schizophrenics medicated with halo-peridol were included in the study. Regional cerebral blood flow was assessed with single-photon emission computed tomography(SPECT) under a resting state. Relative rCBF was compared between two groups. Haloperidol was selected as the antipsychotic drug as it has relatively selective action at the D2 receptor and less active metabolites. Exposed duration was limited from one to three weeks. Results : Haloperidol-medicated schizophrenic patients had a significantly greater increase of relative cerebral perfusion in the right inferior temporal lobe, left inferior frontal lobe, both basal ganglia, left thalamus, both parieto-occipital lobes, and right parietal lobe than drug-naive schizophrenic patients. Haloperidol-medicated schizophrenic patients had a significant decrease of relative cerebral perfusion in left inferior temporal lobe. However, no significant differences in relative rCBF were found between drug-naive and haloperidol-medicated schizophrenic patients in right inferior frontal lobe, right thalamus, both superior temporal lobes, both superior frontal lobes, and left parietal lobe. Conclusion : These findings suggest that antipsychotics affect regional cerebral blood flow, and antipsychotic medication status must be considered in the relative rCBF studies of schizophrenic patients.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Min, Sung Kil(민성길)
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
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