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Positive and negative symptoms and regional cerebral perfusion in antipsychotic-naive schizophrenic patients: a high-resolution SPECT study

Authors
 Sung Kil Min  ;  Suk Kyoon An  ;  Duk-In Jon  ;  Jong Doo Lee 
Citation
 Psychiatry Research-Neuroimaging, Vol.90(3) : 159-168, 1999 
Journal Title
 Psychiatry Research-Neuroimaging 
ISSN
 0165-1781 
Issue Date
1999
MeSH
Adult ; Brain/diagnostic imaging ; Brain/physiopathology* ; Cerebrovascular Circulation* ; Cysteine/analogs & derivatives ; Dominance, Cerebral ; Female ; Frontal Lobe/physiopathology ; Humans ; Male ; Organotechnetium Compounds ; Psychiatric Status Rating Scales ; Radiopharmaceuticals ; Schizophrenia/diagnostic imaging* ; Schizophrenia/physiopathology* ; Schizophrenic Psychology* ; Temporal Lobe/physiopathology ; Thalamus/physiopathology ; Tomography, Emission-Computed, Single-Photon/methods
Abstract
In 17 antipsychotic-naive schizophrenic patients, the scores of positive and negative symptoms of schizophrenia were correlated with relative regional cerebral perfusion measured by 99m-Tc-ECD (ethyl cysteinate dimer) single photon emission computed tomography (SPECT). Scans were performed in subjects at rest. The negative symptom dimension was significantly correlated with a decreased level of perfusion in the left thalamic region. Other non-significant trends were also observed; the positive symptom dimension was related to decreased perfusion in the left temporal region and to increased perfusion in the right frontal region, while the negative symptom dimension was related to increased perfusion in the left frontal region. These findings suggest that the positive and negative symptoms of schizophrenia are related to dysfunctions in different regions of the brain and different lateralized patterns of dysfunction.
Full Text
https://linkinghub.elsevier.com/retrieve/pii/S0925492799000141
DOI
10.1016/s0925-4927(99)00014-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Min, Sung Kil(민성길)
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Jong Doo(이종두)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174353
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