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농축혈소판제제 다회 수혈환자에서의 혈소판수혈불응증 발생빈도와 동종면역 양상

Other Titles
 The Frequency and Characteristics of the Platelet Refractoriness and Alloimmunization in Platelet Concentrate Multiple-Transfused Thrombocytopenic Patients 
Authors
 용동은  ;  김현옥  ;  김현숙  ;  민유홍  ;  송경순  ;  양윤선 
Citation
 Korean Journal of Hematology (대한혈액학회지), Vol.34(2) : 272-280, 1999 
Journal Title
 Korean Journal of Hematology (대한혈액학회지) 
ISSN
 1225-0546 
Issue Date
1999
Keywords
Platelet transfusion ; Platelet refractoriness ; Alloimmunization ; Anti-HLA antibodies ; Platelet-specific antibodies
Abstract
BACKGROUND: Understanding the cause for platelet refractoriness in a given patient is the critical step in determining the strategy for optimum management. The aim of this study was to establish the causes and frequency of platelet refractoriness as well as the incidence of antiHLA antibodies and anti-platelet specific antibodies in multiple transfused thrombocytopenic patients. METHODS: Our study was based on 58 patients requiring platelet transfusions on at least three consecutive occasions from September 1997 to December 1997 in our hospital. The platelet refractoriness was defined as 18-24 hour post-transfusion corrected count increment (CCI) of less than 5,000. Enzyme immunosorbent assay (EIA), panel reactive antibody test (PRA) and Modified antigen capture ELISA (MACE) were applied for the detection of alloimmunization. RESULTS: Thirty-nine patients had episodes of refractoriness (67%). In 39 patients, poor response was seen in 38 patients (97%) with presence of non-immune factors known to be associated with platelet refractoriness. The total rate of alloimmunization was 31%, accounting for fourteen patients (24%) who had HLA antibodies, and four patients (7%) who had platelet specific antibodies. No patient had platelet-specific antibodies in addition to HLA antibodies. From our results, alloimmunization has shown a statistically meaningful relationship with CCI and the use of leukoreduction filtered blood components. CONCLUSION: Our data suggest that immune mechanisms are not the predominant cause of platelet refractoriness and HLA antibodies are produced separately with platelet-specific antibodies, as well as more frequently in alloimmunization.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174337
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