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자외선 조사가 Listeria monocytogenes의 감염에 대한 감수성과 싸이토카인 생성에 미치는 영향

Other Titles
 The Effect of Ultraviolet lrradiation on Susceptibility of Listeria monocytogenes lnfection and the Production of Cytokines 
Authors
 유욱  ;  장수경  ;  김길영  ;  이봉기 
Citation
 Korean Journal of Immunology (대한면역학회지), Vol.21(4) : 353-360, 1999 
Journal Title
 Korean Journal of Immunology (대한면역학회지) 
ISSN
 1015-6453 
Issue Date
1999
Keywords
Ultraviolet B ; IFN-γ ; TNF-α ; IL-12 ; Listeria monocytogenes ; Spleen index
Abstract
Although the effect of ultraviolet (UV) irradiation on immune response was reported to supress cellular immune response, the exact mechanism was not elucidated. As recent development in cytokine research progress, it is well-known that immune response is regulated by cytokines and especially cellular immune response is induced by interferon (IFN)-r and interleukin (IL)-12 which is mainly produced from lymphocytes and macrophages respectively. Therefore our purpose was to elucidate the UV effect on cellular immune response and its mechanism. We have investigated the changes of host resistance by injection of Listeria monocytogenes which is an intracellular parasite after UVB irradiation in C57BL/6 mice which is known to have relatively strong cellular immune response. In addition we also have investigated the changes in the production of IFN-r from lymphocytes and the production of tumor necrosis factor (TNF)-a and IL-12 from macrophages in mice by UVB irradiation. The increase of mouse spleen index and susceptibility of iisteria monocytogenes infection was correlated with the decreased production of IFN-r, TNF-a and IL-12, which was known to induce the suppression of cellular imrnune response.
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=1917443
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bong Ki(이봉기)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174170
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