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만성 B형 간질환 환자에서 라미부딘 장기투여의 치료효과

Other Titles
 The Effect of Long-term Lamivudine Therapy for Chronic Liver Disease due to Hepatitis B Virus 
Authors
 한광협  ;  김진석  ;  정효영  ;  안상훈  ;  백용한  ;  이관식  ;  전재윤  ;  문영명 
Citation
 Korean Journal of Hepatology (대한간학회지), Vol.5(2) : 97-104, 1999 
Journal Title
 Korean Journal of Hepatology (대한간학회지) 
ISSN
 1738-222X 
Issue Date
1999
Keywords
Lamivudine ; HBV DNA breakthrough ; ALT breakthrough ; HBeAg seroconversion ; YMDD mutant
Abstract
Background/Aims : We studied to evaluate the virological and biochemical responses to lamivudine and to detect YMDD mutants in patients who received long-term lamivudine therapy. Method : We conducted a one-year trial of lamivudine in 45 Korean patients with chronic liver disease due to hepatitis B virus. The patients were treated with a single oral average dose of 100 mg of lamivudine every day for 12 months. Results : The suppression of serum HBV DNA was sustained in 77.8% of the patients and the normalization of serum ALT in 80%. The proportions of patients with HBeAg seroconversion were 25%. YMDD mutants were detected in 4 of 8 patients who showed sustained HBV DNA and serum ALT response (n=31) and in 3 of 8 patients who showed HBV DNA or serum ALT breakthrough (n=9). The response to lamivudine therapy in HBeAg-negative patients was excellent. Conclusion : Lamivudine therapy resulted in a significant virological and biochemical improvements and were well tolerated. But, YMDD mutants were detected during lamivudine therapy.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Paik, Yong Han(백용한)
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174098
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