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자궁경부암 환자에서 Bcl-2 gene과 Cd-44 molecules의 발현의 임상적 의의 및 예후인자와의 상관관계

Other Titles
 The Clinical Significance of Expression of Bcl-2 and CD-44 molecules in Cervical Cancer and Its Correlation with Known Prognostic Factors 
Authors
 김동규  ;  정현용  ;  김영태  ;  이병석  ;  서경  ;  이윤호  ;  이국  ;  김재욱  ;  조남훈 
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.42(11) : 2531-2535, 1999 
Journal Title
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) 
ISSN
 0494-4755 
Issue Date
1999
Keywords
Bcl-2 gene ; CD-44 molecules ; spliced variant form V6 ; cervical cancer ; 자궁경부암 ; CD-44분자
Abstract
OBJECTIVE: The study was designed to investigate the expression of Bcl-2 and CD-44 molecules in cervical cancer and compare the results with known clinical prognostic factors, and lastly to define the roles of Bcl-2 and CD-44 molecules in tumorigenesis and metastasis of cervical cancer.0aMETHODS: A total of 85 patients were enrolled in this study and retrospective analysis of prognostic factors were compared with immunohistochemical staining of Bcl-2 and CD-44. RESULTS: The expression of Bcl-2 was relatively even when we compared with stage, cell types, grade and lymph node metastasis. And the CD-44 spliced variant form V6 expression was significantly strong in higher stage and positive lymph node metastasis but cell types and grade of tumor does not correlated with status of CD-44 expression. 0aCONCLUSION: Bcl-2 expression in cervical cancer does not correlate with clinical prognostic factors, but CD-44 spliced variant V6 form does correlated with poor prognostic factors. CD-44 may play a role in the process of the tumor metastasis and poor prognosis.
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=1857574
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174031
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