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Pyrithione, a zinc ionophore, inhibits NF-kappaB activation

DC Field Value Language
dc.contributor.author김철훈-
dc.contributor.author문석준-
dc.contributor.author서정택-
dc.contributor.author안영수-
dc.date.accessioned2020-01-23T05:02:03Z-
dc.date.available2020-01-23T05:02:03Z-
dc.date.issued1999-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173947-
dc.description.abstractPyrrolidine dithiocarbamate (PDTC) suppresses NF-kappaB activity and exhibits cytotoxic effects in bovine cerebral endothelial cells (BCECs), and we have previously reported that these PDTC effects were accompanied by an increase in intracellular zinc levels. To further explore the role of zinc in the modulation of NF-kappaB activation, we studied the effect of pyrithione, a zinc ionophore, on NF-kappaB activation in BCECs. Pyrithione inhibited NF-kappaB activity in a time- and dose-dependent manner. Ca-EDTA, but not Zn-EDTA, prevented pyrithione inhibition of NF-kappaB activity. Pyrithione increased the intracellular zinc level within 15 min. This effect was also abolished by Ca-EDTA, but not by Zn-EDTA. The potency of pyrithione on NF-kappaB inhibition and zinc influx was approximately one order of magnitude more potent than PDTC. These findings establish the regulatory role of intracellular zinc levels on NF-kappaB activity in BCECs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfBiochemical and Biophysical Research Communications-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCalcium/metabolism-
dc.subject.MESHCattle-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHEnzyme Activation/drug effects-
dc.subject.MESHIonophores/pharmacology*-
dc.subject.MESHNF-kappa B/metabolism*-
dc.subject.MESHPyridines/pharmacology*-
dc.subject.MESHPyrrolidines/pharmacology*-
dc.subject.MESHTetradecanoylphorbol Acetate/pharmacology-
dc.subject.MESHThiocarbamates/pharmacology*-
dc.subject.MESHThiones-
dc.subject.MESHTime Factors-
dc.subject.MESHTumor Necrosis Factor-alpha/pharmacology-
dc.subject.MESHZinc/metabolism*-
dc.titlePyrithione, a zinc ionophore, inhibits NF-kappaB activation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학교실)-
dc.contributor.googleauthorChul Hoon Kim-
dc.contributor.googleauthorJoo Hee Kim-
dc.contributor.googleauthorSeok Jun Moon-
dc.contributor.googleauthorKwang Chul Chung-
dc.contributor.googleauthorChung Y. Hsu-
dc.contributor.googleauthorJeong Taeg Seo-
dc.contributor.googleauthorYoung Soo Ahn-
dc.identifier.doi10.1006/bbrc.1999.0814-
dc.contributor.localIdA01057-
dc.contributor.localIdA01358-
dc.contributor.localIdA01905-
dc.contributor.localIdA02246-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid10364448-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006291X99908148-
dc.contributor.alternativeNameKim, Chul Hoon-
dc.contributor.affiliatedAuthor김철훈-
dc.contributor.affiliatedAuthor문석준-
dc.contributor.affiliatedAuthor서정택-
dc.contributor.affiliatedAuthor안영수-
dc.citation.volume259-
dc.citation.number3-
dc.citation.startPage505-
dc.citation.endPage509-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, Vol.259(3) : 505-509, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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