Cited 65 times in
Pyrithione, a zinc ionophore, inhibits NF-kappaB activation
DC Field | Value | Language |
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dc.contributor.author | 김철훈 | - |
dc.contributor.author | 문석준 | - |
dc.contributor.author | 서정택 | - |
dc.contributor.author | 안영수 | - |
dc.date.accessioned | 2020-01-23T05:02:03Z | - |
dc.date.available | 2020-01-23T05:02:03Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173947 | - |
dc.description.abstract | Pyrrolidine dithiocarbamate (PDTC) suppresses NF-kappaB activity and exhibits cytotoxic effects in bovine cerebral endothelial cells (BCECs), and we have previously reported that these PDTC effects were accompanied by an increase in intracellular zinc levels. To further explore the role of zinc in the modulation of NF-kappaB activation, we studied the effect of pyrithione, a zinc ionophore, on NF-kappaB activation in BCECs. Pyrithione inhibited NF-kappaB activity in a time- and dose-dependent manner. Ca-EDTA, but not Zn-EDTA, prevented pyrithione inhibition of NF-kappaB activity. Pyrithione increased the intracellular zinc level within 15 min. This effect was also abolished by Ca-EDTA, but not by Zn-EDTA. The potency of pyrithione on NF-kappaB inhibition and zinc influx was approximately one order of magnitude more potent than PDTC. These findings establish the regulatory role of intracellular zinc levels on NF-kappaB activity in BCECs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | Biochemical and Biophysical Research Communications | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Cattle | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Enzyme Activation/drug effects | - |
dc.subject.MESH | Ionophores/pharmacology* | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Pyridines/pharmacology* | - |
dc.subject.MESH | Pyrrolidines/pharmacology* | - |
dc.subject.MESH | Tetradecanoylphorbol Acetate/pharmacology | - |
dc.subject.MESH | Thiocarbamates/pharmacology* | - |
dc.subject.MESH | Thiones | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/pharmacology | - |
dc.subject.MESH | Zinc/metabolism* | - |
dc.title | Pyrithione, a zinc ionophore, inhibits NF-kappaB activation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Joo Hee Kim | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.contributor.googleauthor | Kwang Chul Chung | - |
dc.contributor.googleauthor | Chung Y. Hsu | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.contributor.googleauthor | Young Soo Ahn | - |
dc.identifier.doi | 10.1006/bbrc.1999.0814 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A01905 | - |
dc.contributor.localId | A02246 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 10364448 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X99908148 | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | 김철훈 | - |
dc.contributor.affiliatedAuthor | 문석준 | - |
dc.contributor.affiliatedAuthor | 서정택 | - |
dc.contributor.affiliatedAuthor | 안영수 | - |
dc.citation.volume | 259 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 505 | - |
dc.citation.endPage | 509 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, Vol.259(3) : 505-509, 1999 | - |
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