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Differential expression of nitric oxide synthase in human stomach cancer

Authors
 Eunjin Koh  ;  Sung Hoon Noh  ;  Young Don Lee  ;  Hoi Young Lee  ;  Jeung-Whan Han  ;  Hyang Woo Lee  ;  Sungyoul Hong 
Citation
 CANCER LETTERS, Vol.146(2) : 173-180, 1999 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
1999
MeSH
Adult ; Aged ; Female ; Guanidines/pharmacology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase/metabolism* ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; RNA, Messenger/analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach Neoplasms/enzymology* ; Stomach Neoplasms/pathology
Abstract
The level of expression and cellular localization of isoenzymes of nitric oxide synthase (NOS) was detected in human stomach tumor tissues. Tumor tissues showed 70% higher activity of NOS than that of normal tissues (P < 0.01). Poorly differentiated adenocarcinoma tend to have higher activity (P < 0.05) than well differentiated and moderately differentiated tumor tissues. Aminoguanidine (AG), 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), NG-monomethyl-L-arginine (L-NMMA), and Nomega-nitro-L-arginine (L-NNA) inhibited NOS activity in tumor tissues by 18, 14, 11 and 13%, respectively. The TNF-alpha mRNA expression was correlated with the inducible NOS (iNOS) level, which was high in adenocarcinomas and low in normal tissues. Tumor tissues showed higher expression of iNOS in gland epithelial cells but the level of eNOS was significantly decreased with an exception of concentrated localization in the proliferating capillary endothelium. These results revealed that isoforms of NOS might contribute differentially to growth and progression of human stomach tumor.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383599002657
DOI
10.1016/s0304-3835(99)00265-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173766
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