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5-알파환원효소억제제(Finasteride) 투약 중단 후 보이는 전립선 크기, 전립선이행대 크기 및 PSA 변화 양상
DC Field | Value | Language |
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dc.contributor.author | Hong, Sung Joon | - |
dc.date.accessioned | 2020-01-03T08:18:18Z | - |
dc.date.available | 2020-01-03T08:18:18Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0494-4747 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173713 | - |
dc.description.abstract | PURPOSE: Finasteride is an inhibitor of human 5alpha-reductase, which results in a decrease in plasma and intraprostatic dihydrotestosterone(DHT) level. We investigated the changes of prostate volume(PV), transitional zone volume(TV), and PSA during and after administration of finasteride. MATERIALS AND METHODS: From 1995, 32 BPH patients treated with finasteride underwent surveillance after cessation of finasteride. Surveillance included measurements of PV, TV and PSA every 3 to 6 months. The mean age of the patients was 66.7 years(57-73). The mean duration of treatment and cessation were 8.6 months(6-12) and 8.0 months(6-12), respectively. The changes in PV, TV, and PSA were compared. RESULTS: The mean initial PV, TV, PSA were 45.7cc, 22.5cc, 2.72ng/ml, respectively. After treatment, PV, TV, PSA were reduced to 72.7%, 67.1%, 64.7% and 68.0%, 61.4%, 57.3% and 59.4%, 55.0%, 52.5% of the original values at 3, 6 and 12 months, respectively. The reduction rate was maximum after the first 3 months(p=0.001). After discontinuing finasteride, PV, TV, PSA recovered to 71.0%, 71.2% 63.9% and 84.0%, 82.3%, 67.6% and 90.4%, 85.1%, 74.1% at 3, 6 and 12 months, respectively. The recovery rates of PV and TV after 3 and 6 months were equal. However, recovery rate of PSA was maximum at 3 months and after then, constant until 12 months. CONCLUSIONS: During first 3 months` treatment, the decreasing rates of PV, TV and PSA were very considerable, after then, reduced. After cessation of medication the recovery rates of PV, TV were constant during first 6 months but PSA was maximum at first 3 months. The changes in clinical parameters during administration were fully recovered but it took slightly longer periods after cessation compared to those during of treatment. PSA is probably a predictor in the assessment of volume changes. | - |
dc.description.statementOfResponsibility | prohibition | - |
dc.language | Korean | - |
dc.publisher | 대한비뇨기과학회 | - |
dc.relation.isPartOf | Korean Journal of Urology (대한비뇨기과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 5-알파환원효소억제제(Finasteride) 투약 중단 후 보이는 전립선 크기, 전립선이행대 크기 및 PSA 변화 양상 | - |
dc.title.alternative | Changes in Prostate Volume, Transitional Zone Volume and PSA after Cessation of the Finasteride | - |
dc.type | Article | - |
dc.contributor.college | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | 홍주의 | - |
dc.contributor.googleauthor | 홍성준 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02135 | - |
dc.subject.keyword | Finasteride | - |
dc.subject.keyword | BPH | - |
dc.subject.keyword | Prostate volume | - |
dc.subject.keyword | PSA | - |
dc.contributor.alternativeName | College of Medicine (의과대학) | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.citation.volume | 40 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1519 | - |
dc.citation.endPage | 1524 | - |
dc.identifier.bibliographicCitation | Korean Journal of Urology (대한비뇨기과학회지), Vol.40(11) : 1519-1524, 1999 | - |
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