Cited 22 times in
Clinicopathological and biomolecular characteristics of stage IIB/IIC and stage IIIA colon cancer: Insight into the survival paradox
DC Field | Value | Language |
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dc.contributor.author | 김가람 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 조민수 | - |
dc.contributor.author | 한윤대 | - |
dc.contributor.author | 허혁 | - |
dc.date.accessioned | 2019-12-18T01:15:07Z | - |
dc.date.available | 2019-12-18T01:15:07Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173440 | - |
dc.description.abstract | BACKGROUND: A survival paradox of stage IIB/IIC and IIIA colon cancer has been consistently observed throughout revisions of the TNM system. This study aimed to understand this paradox with clinicopathological and molecular differences. METHODS: Clinicopathological characteristics of patients with pathologically confirmed stage IIB/IIC or IIIA colon cancer were retrospectively reviewed from a database. Publicly available molecular data were retrieved, and intrinsic subtypes were identified and subjected to gene sets enrichment analysis (GSEA). RESULTS: Among the 159 patients included in the clinicopathological analysis, those at stage IIB/IIC had worse 3-year disease-free and overall survival than those at stage IIIA (59.3% vs 91.7%, P < 0.001 and 82.7% vs 98.5%, P < 0.001, respectively), even after adjusting for confounding factors. Data of 95 patients were retrieved from public databases, demonstrating a higher frequency of the microsatellite instable subtype in stage IIB/IIC. The consensus molecular subtype distribution pattern differed between the groups. The GSEA further suggested the protumor inflammatory reaction might be more prominent in stage IIB/IIC. CONCLUSIONS: The survival paradox in colon cancer was confirmed and appears to be a multifactorial phenomenon not attributed to a single clinicopathologic factor. However, the greater molecular heterogeneity in stage IIB/IIC could contribute to the poor prognosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | - |
dc.subject.MESH | Colonic Neoplasms/drug therapy | - |
dc.subject.MESH | Colonic Neoplasms/genetics* | - |
dc.subject.MESH | Colonic Neoplasms/mortality | - |
dc.subject.MESH | Colonic Neoplasms/pathology* | - |
dc.subject.MESH | DNA Methylation | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microsatellite Instability | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins p21(ras)/genetics | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Clinicopathological and biomolecular characteristics of stage IIB/IIC and stage IIIA colon cancer: Insight into the survival paradox | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Ho Seung Kim | - |
dc.contributor.googleauthor | Kyeong Min Kim | - |
dc.contributor.googleauthor | Sat Byol Lee | - |
dc.contributor.googleauthor | Ga Ram Kim | - |
dc.contributor.googleauthor | Yoon Dae Han | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.identifier.doi | 10.1002/jso.25515 | - |
dc.contributor.localId | A00284 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A03817 | - |
dc.contributor.localId | A04313 | - |
dc.contributor.localId | A04373 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 31134644 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/jso.25515 | - |
dc.subject.keyword | colon cancer | - |
dc.subject.keyword | stage IIB/IIC | - |
dc.subject.keyword | stage IIIA | - |
dc.subject.keyword | survival paradox | - |
dc.contributor.alternativeName | Kim, Ga Ram | - |
dc.contributor.affiliatedAuthor | 김가람 | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.contributor.affiliatedAuthor | 민병소 | - |
dc.contributor.affiliatedAuthor | 이강영 | - |
dc.contributor.affiliatedAuthor | 조민수 | - |
dc.contributor.affiliatedAuthor | 한윤대 | - |
dc.contributor.affiliatedAuthor | 허혁 | - |
dc.citation.volume | 120 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 423 | - |
dc.citation.endPage | 430 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.120(3) : 423-430, 2019 | - |
dc.identifier.rimsid | 63856 | - |
dc.type.rims | ART | - |
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