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Clinicopathological and biomolecular characteristics of stage IIB/IIC and stage IIIA colon cancer: Insight into the survival paradox

DC FieldValueLanguage
dc.contributor.author김가람-
dc.contributor.author김남규-
dc.contributor.author민병소-
dc.contributor.author이강영-
dc.contributor.author조민수-
dc.contributor.author한윤대-
dc.contributor.author허혁-
dc.date.accessioned2019-12-18T01:15:07Z-
dc.date.available2019-12-18T01:15:07Z-
dc.date.issued2019-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173440-
dc.description.abstractBACKGROUND: A survival paradox of stage IIB/IIC and IIIA colon cancer has been consistently observed throughout revisions of the TNM system. This study aimed to understand this paradox with clinicopathological and molecular differences. METHODS: Clinicopathological characteristics of patients with pathologically confirmed stage IIB/IIC or IIIA colon cancer were retrospectively reviewed from a database. Publicly available molecular data were retrieved, and intrinsic subtypes were identified and subjected to gene sets enrichment analysis (GSEA). RESULTS: Among the 159 patients included in the clinicopathological analysis, those at stage IIB/IIC had worse 3-year disease-free and overall survival than those at stage IIIA (59.3% vs 91.7%, P < 0.001 and 82.7% vs 98.5%, P < 0.001, respectively), even after adjusting for confounding factors. Data of 95 patients were retrieved from public databases, demonstrating a higher frequency of the microsatellite instable subtype in stage IIB/IIC. The consensus molecular subtype distribution pattern differed between the groups. The GSEA further suggested the protumor inflammatory reaction might be more prominent in stage IIB/IIC. CONCLUSIONS: The survival paradox in colon cancer was confirmed and appears to be a multifactorial phenomenon not attributed to a single clinicopathologic factor. However, the greater molecular heterogeneity in stage IIB/IIC could contribute to the poor prognosis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJOURNAL OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use-
dc.subject.MESHColonic Neoplasms/drug therapy-
dc.subject.MESHColonic Neoplasms/genetics*-
dc.subject.MESHColonic Neoplasms/mortality-
dc.subject.MESHColonic Neoplasms/pathology*-
dc.subject.MESHDNA Methylation-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMicrosatellite Instability-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins B-raf/genetics-
dc.subject.MESHProto-Oncogene Proteins p21(ras)/genetics-
dc.subject.MESHRetrospective Studies-
dc.titleClinicopathological and biomolecular characteristics of stage IIB/IIC and stage IIIA colon cancer: Insight into the survival paradox-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorHo Seung Kim-
dc.contributor.googleauthorKyeong Min Kim-
dc.contributor.googleauthorSat Byol Lee-
dc.contributor.googleauthorGa Ram Kim-
dc.contributor.googleauthorYoon Dae Han-
dc.contributor.googleauthorMin Soo Cho-
dc.contributor.googleauthorHyuk Hur-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorByung Soh Min-
dc.identifier.doi10.1002/jso.25515-
dc.contributor.localIdA00284-
dc.contributor.localIdA00353-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.contributor.localIdA01402-
dc.contributor.localIdA02640-
dc.contributor.localIdA02640-
dc.contributor.localIdA03817-
dc.contributor.localIdA03817-
dc.contributor.localIdA04313-
dc.contributor.localIdA04313-
dc.contributor.localIdA04373-
dc.contributor.localIdA04373-
dc.relation.journalcodeJ01762-
dc.identifier.eissn1096-9098-
dc.identifier.pmid31134644-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/jso.25515-
dc.subject.keywordcolon cancer-
dc.subject.keywordstage IIB/IIC-
dc.subject.keywordstage IIIA-
dc.subject.keywordsurvival paradox-
dc.contributor.alternativeNameKim, Ga Ram-
dc.contributor.affiliatedAuthor김가람-
dc.contributor.affiliatedAuthor김남규-
dc.contributor.affiliatedAuthor김남규-
dc.contributor.affiliatedAuthor민병소-
dc.contributor.affiliatedAuthor민병소-
dc.contributor.affiliatedAuthor이강영-
dc.contributor.affiliatedAuthor이강영-
dc.contributor.affiliatedAuthor조민수-
dc.contributor.affiliatedAuthor조민수-
dc.contributor.affiliatedAuthor한윤대-
dc.contributor.affiliatedAuthor한윤대-
dc.contributor.affiliatedAuthor허혁-
dc.contributor.affiliatedAuthor허혁-
dc.citation.volume120-
dc.citation.number3-
dc.citation.startPage423-
dc.citation.endPage430-
dc.identifier.bibliographicCitationJOURNAL OF SURGICAL ONCOLOGY, Vol.120(3) : 423-430, 2019-
dc.identifier.rimsid63856-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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