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Application of Sepsis-3 Criteria to Korean Patients with Critical Illnesses

Authors
 Jae Yeol Kim  ;  Hwan Il Kim  ;  Gee Young Suh  ;  Sang Won Yoon  ;  Tae-Yop Kim  ;  Sang Haak Lee  ;  Jae Young Moon  ;  Jae-Young Kwon  ;  Sungwon Na  ;  Ho Geol Ryu  ;  Jisook Park  ;  Younsuck Koh 
Citation
 ACUTE AND CRITICAL CARE, Vol.34(1) : 30-37, 2019 
Journal Title
 ACUTE AND CRITICAL CARE 
ISSN
 2586-6052 
Issue Date
2019
Keywords
Sepsis ; Sepsis-3 ; intensive care units ; organ dysfunction ; septic shock
Abstract
Background: The 2016 Society of Critical Care Medicine (SCCM)/European Society of Intensive Care Medicine (ESICM) task force for Sepsis-3 devised new definitions for sepsis, sepsis with organ dysfunction and septic shock. Although Sepsis-3 was data-driven, evidence-based approach, East Asian descents comprised minor portions of the project population. Methods: We selected Korean participants from the fever and antipyretics in critically ill patients evaluation (FACE) study, a joint study between Korea and Japan. We calculated the concordance rates for sepsis diagnosis between Sepsis-2 and Sepsis-3 criteria and evaluated mortality rates of sepsis, sepsis with organ dysfunction, and septic shock by Sepsis-3 criteria using the selected data. Results: Korean participants of the FACE study were 913 (383 with sepsis and 530 without sepsis by Sepsis-2 criteria). The concordance rate for sepsis diagnosis between Sepsis-2 and Sepsis-3 criteria was 55.4%. The intensive care unit (ICU) and 28-day mortality rates of sepsis, sepsis with organ dysfunction, and septic shock patients according to Sepsis-3 criteria were 26.2% and 31.0%, 27.5% and 32.5%, and 40.8% and 43.4%, respectively. The quick Sequential Organ Failure Assessment (qSOFA) was inferior not only to SOFA but also to systemic inflammatory response syndrome (SIRS) for predicting ICU and 28-day mortality. Conclusions: The concordance rates for sepsis diagnosis between Sepsis-2 and Sepsis-3 criteria were low. Mortality rate for septic shock in Koreans was consistent with estimates made by the 2016 SCCM/ESICM task force. SOFA and SIRS were better than qSOFA for predicting ICU and 28-day mortality in Korean ICU patients.
Files in This Item:
T201904511.pdf Download
DOI
10.4266/acc.2018.00318
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Na, Sungwon(나성원) ORCID logo https://orcid.org/0000-0002-1170-8042
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173337
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