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Striatal dopamine activity and myocardial 123I-metaiodobenzylguanidine uptake in early Parkinson's disease

Authors
 Yoon-Sang Oh  ;  Joong-Seok Kim  ;  Sang-Won Yoo  ;  Eo-Jin Hwang  ;  Chul Hyoung Lyoo  ;  Kwang-Soo Lee 
Citation
 PARKINSONISM & RELATED DISORDERS, Vol.63 : 156-161, 2019 
Journal Title
 PARKINSONISM & RELATED DISORDERS 
ISSN
 1353-8020 
Issue Date
2019
Keywords
(123)I-metaiodobenzylguanidine scintigraphy ; Dopamine transporter scan ; Parkinson's disease
Abstract
INTRODUCTION: Dopamine transporter imaging and myocardial 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy have been widely used to diagnose and discriminate degenerative parkinsonism. Many studies have reported that both imaging findings are associated with a variety of motor and non-motor phenomena in Parkinson's disease (PD). However, the association between striatal dopamine activity and myocardial 123I-MIBG uptake has not been well investigated. The objective of this study is to identify the dopamine transporter activity of the corpus striatum and thalamus according to myocardial 123I-MIBG uptake in PD. METHODS: Ninety-six newly diagnosed, non-medicated PD patients were enrolled. All patients underwent 123I-MIBG myocardial scintigraphy, positron emission tomography (PET) using 18FN-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane and T1-weighted magnetic resonance imaging (MRI). Patients were stratified into normal and decreased 123I-MIBG groups according to their delayed heart-to-mediastinum ratio (cutoff value = 1.78). After normalizing the PET images with spatially normalized MRI, the regional standardized uptake value ratios (SUVRs) were analyzed with a volume-of-interest template between the two groups. RESULTS: Thirty-one patients showed normal myocardial 123I-MIBG uptake, and 65 patients showed reduced uptake. The SUVR of the globus pallidus in the group with reduced 123I-MIBG uptake was significantly lower than the SUVR in the normal 123I-MIBG uptake group. The heart-to-mediastinum ratio was correlated well with the SUVR of the globus pallidus, independent of age, disease duration, and the severity of motor symptoms. CONCLUSION: Early PD patients with normal 123I-MIBG uptake showed a relatively preserved dopamine reserve in the globus pallidus than patients with reduced 123I-MIBG uptake.
Full Text
https://www.sciencedirect.com/science/article/pii/S1353802019300586
DOI
10.1016/j.parkreldis.2019.02.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173302
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