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Striatal dopamine activity and myocardial 123I-metaiodobenzylguanidine uptake in early Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 류철형 | - |
dc.date.accessioned | 2019-12-18T00:58:29Z | - |
dc.date.available | 2019-12-18T00:58:29Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173302 | - |
dc.description.abstract | INTRODUCTION: Dopamine transporter imaging and myocardial 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy have been widely used to diagnose and discriminate degenerative parkinsonism. Many studies have reported that both imaging findings are associated with a variety of motor and non-motor phenomena in Parkinson's disease (PD). However, the association between striatal dopamine activity and myocardial 123I-MIBG uptake has not been well investigated. The objective of this study is to identify the dopamine transporter activity of the corpus striatum and thalamus according to myocardial 123I-MIBG uptake in PD. METHODS: Ninety-six newly diagnosed, non-medicated PD patients were enrolled. All patients underwent 123I-MIBG myocardial scintigraphy, positron emission tomography (PET) using 18FN-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane and T1-weighted magnetic resonance imaging (MRI). Patients were stratified into normal and decreased 123I-MIBG groups according to their delayed heart-to-mediastinum ratio (cutoff value = 1.78). After normalizing the PET images with spatially normalized MRI, the regional standardized uptake value ratios (SUVRs) were analyzed with a volume-of-interest template between the two groups. RESULTS: Thirty-one patients showed normal myocardial 123I-MIBG uptake, and 65 patients showed reduced uptake. The SUVR of the globus pallidus in the group with reduced 123I-MIBG uptake was significantly lower than the SUVR in the normal 123I-MIBG uptake group. The heart-to-mediastinum ratio was correlated well with the SUVR of the globus pallidus, independent of age, disease duration, and the severity of motor symptoms. CONCLUSION: Early PD patients with normal 123I-MIBG uptake showed a relatively preserved dopamine reserve in the globus pallidus than patients with reduced 123I-MIBG uptake. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | PARKINSONISM & RELATED DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Striatal dopamine activity and myocardial 123I-metaiodobenzylguanidine uptake in early Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Yoon-Sang Oh | - |
dc.contributor.googleauthor | Joong-Seok Kim | - |
dc.contributor.googleauthor | Sang-Won Yoo | - |
dc.contributor.googleauthor | Eo-Jin Hwang | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.contributor.googleauthor | Kwang-Soo Lee | - |
dc.identifier.doi | 10.1016/j.parkreldis.2019.02.012 | - |
dc.contributor.localId | A01333 | - |
dc.relation.journalcode | J02468 | - |
dc.identifier.eissn | 1873-5126 | - |
dc.identifier.pmid | 30796009 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1353802019300586 | - |
dc.subject.keyword | (123)I-metaiodobenzylguanidine scintigraphy | - |
dc.subject.keyword | Dopamine transporter scan | - |
dc.subject.keyword | Parkinson's disease | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | 류철형 | - |
dc.citation.volume | 63 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 161 | - |
dc.identifier.bibliographicCitation | PARKINSONISM & RELATED DISORDERS, Vol.63 : 156-161, 2019 | - |
dc.identifier.rimsid | 64074 | - |
dc.type.rims | ART | - |
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