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The association of depression with lower urinary tract symptoms: data from the National Health and Nutrition Examination Survey, 2005-2008

 Jee Soo Park  ;  Won Sik Ham  ;  Chang Hee Hong  ;  Byung Ha Chung  ;  Kyo Chul Koo 
 PEERJ, Vol.7 : e7795, 2019 
Journal Title
Issue Date
Depression ; Lower urinary tract symptoms ; NHANES
Background: To identify the factors associated with lower urinary tract symptoms (LUTS), we investigated associations between psychological factors, including depression and sleep disorders, and LUTS using the National Health and Nutrition Examination Survey (NHANES) database.

Materials and Methods: The NHANES database was examined for the period of 2005 to 2008. Men older than 40 years, who had completed questionnaires surveying their kidney/urologic, prostate, mental health, and sleep conditions were included in this study. LUTS was defined as the presence of two or more of the following symptoms: incomplete emptying, urinary hesitancy, urinary frequency, and nocturia. Multivariable models using logistic regression were used to compare groups of men with or without LUTS.

Results: Of 1,820 participants, 110 (6.1%) men reported depression, and 235 (12.9%) presented with LUTS. Men with LUTS were older and had a significantly higher prevalence of depression and unemployment. Sleep disorder was not associated with LUTS. Multivariable logistic regression models demonstrated that men reporting moderate depression had the highest age-adjusted odds (odds ratio = 5.89, 95% CI [3.44-10.11]; p < 0.001) of reporting clinical LUTS.

Conclusions: A significant association was observed between LUTS and depression, and between LUTS and employment status. Although the pathophysiology of these relationships is unclear, physicians should consider multi-disciplinary evaluation and treatment approaches for LUTS.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Koo, Kyo Chul(구교철) ORCID logo https://orcid.org/0000-0001-7303-6256
Park, Jee Soo(박지수) ORCID logo https://orcid.org/0000-0001-9976-6599
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
Hong, Chang Hee(홍창희) ORCID logo https://orcid.org/0000-0002-0946-7702
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