Outcomes of pathologically localized high-grade prostate cancer treated with radical prostatectomy

Abstract

Adjuvant radiation therapy (ART) is recommended without consideration of radical prostatectomy Gleason score (RP GS) for cases with adverse features. We compared the outcomes of pathologically localized high-grade (GS 8-10) prostate cancer (PC) with those of pT3 GS 7 PC. A total of 1585 men who underwent RP between 1995 and 2015 comprised the cohort, which was divided into group 1 (RP GS 7 (3+4) and pT3; n=760), group 2 (RP GS 7(4+ 3) and pT3; n= 565), and group 3 (RP GS 8-10 and pT2; n= 260). Biochemical recurrence (BCR), all-cause mortality (ACM), and PC-specific mortality (PCSM) risk were compared among groups using Cox regression and competing risk analysis. At a median follow-up of 58 months (interquartile range: 37-85), 721 men experienced BCR and 84 died (22 due to PC). BCR-free survival rates were lower in group 3 than in group 1 (P<.001); nevertheless, no difference was observed between groups 2 and 3 (P=.638). Furthermore, no difference in ACM was noted among groups. PCSM rates were higher in group 3 than in groups 1 and 2 (P=.001 and P=.005, respectively). This association persisted in multivariate models after adjustment for clinicopathological variables. Patients with RP GS 8-10 and pT2 PC had higher BCR and PCSM rates than those with RP GS 7 and pT3 PC. Localized highgrade PC should be considered in decision-making for ART.