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Derepression of matrix metalloproteinase gene transcription and an emphysema-like phenotype in transcription factor Zbtb7c knockout mouse lungs

Authors
 Bu‐Nam Jeon  ;  Ji‐Yang Song  ;  Jin Won Huh  ;  Woo‐Ick Yang  ;  Man‐Wook Hur 
Citation
 FEBS LETTERS, Vol.593(18) : 2665-2674, 2019 
Journal Title
 FEBS LETTERS 
ISSN
 0014-5793 
Issue Date
2019
Keywords
Zbtb7c (Kr-pok) ; cigarette smoking ; emphysema ; matrix metalloproteinases
Abstract
Dysregulated matrix metalloproteinase (MMP) gene expression is a major cause of the degradation of lung tissue that is integral to emphysema pathogenesis. Cigarette smoking (CS) increases MMP gene expression, a major contributor to emphysema development. We previously reported that Zbtb7c is a transcriptional repressor of several Mmp genes (Mmps-8, -10, -13, and -16). Here, we show that Zbtb7c knockout mice have mild emphysema-like phenotypes, including alveolar wall destruction, enlarged alveoli, and upregulated Mmp genes. Alveolar size and Mmp gene expression in Zbtb7c-/- mouse lungs are increased more severely upon exposure to CS, compared to those of Zbtb7c+/+ mouse lungs. These observations suggest that Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema.
Full Text
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13501
DOI
10.10023.1873-34568
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Song, Ji‐Yang(송지양)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Jeon, Bu Nam(전부남)
Hur, Man Wook(허만욱) ORCID logo https://orcid.org/0000-0002-3416-1334
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173157
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