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The association between progression of coronary artery calcium and colorectal adenoma: A retrospective follow-up study of asymptomatic Koreans

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dc.contributor.author박재준-
dc.contributor.author박효진-
dc.contributor.author백수정-
dc.contributor.author이병권-
dc.contributor.author이혜선-
dc.contributor.author한동희-
dc.date.accessioned2019-12-18T00:38:10Z-
dc.date.available2019-12-18T00:38:10Z-
dc.date.issued2019-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173152-
dc.description.abstractThe potential relationship between coronary artery calcium (CAC) and colorectal adenoma has been widely indicated. This study aimed to investigate the relationship between the risk of colorectal adenoma and CAC progression in asymptomatic Korean adults who underwent serial assessments by colonoscopy and CAC scan.A total of 754 asymptomatic participants, who had undergone serial CAC scans and colonoscopies for screening, were enrolled. Changes in CAC were assessed according to the absolute change between baseline and follow-up results. CAC progression was defined using Multi-Ethnic Study of Atherosclerosis method. Risk for adenoma at follow-up colonoscopy was determined using hazard ratio (HR) by Cox regression. The area under the receiver operating characteristic (ROC) curve was measured.The mean follow-up duration was 3.4 ± 2.5 years. CAC progression was found in 215 participants (28.5%). Participants with adenoma at index colonoscopy showed a higher rate of CAC progression than those without (38.8% vs 23.6%, P < .01). In participants with adenoma at index colonoscopy, CAC progression significantly increased the cumulative risk for adenoma at follow-up colonoscopy (HR = 1.48, 95% confidence interval [CI] 1.06-2.06, log-rank P = .021). In multivariate analysis, male sex (HR = 2.57, 95% CI 1.22-5.42, P = .013), ≥3 adenomas at index colonoscopy (HR = 2.60, 95% CI 1.16-5.85, P = .021), and CAC progression (HR = 2.74, 95% CI 1.48-5.08, P = .001) increased the risk of adenoma at follow-up colonoscopy. In participants without adenoma at index colonoscopy, neither baseline CAC presence nor CAC progression increased the risk of adenoma at follow-up colonoscopy. The interaction between CAC progression and adenoma at index colonoscopy was significant in multivariable model (P = .005). In the ROC analysis, AUC of CAC progression for adenoma at follow-up colonoscopy was 0.625 (95% CI 0.567-0.684, P < .001) in participants with adenoma at index colonoscopy.Participants with CAC progression, who are at high risk of coronary atherosclerosis, may need to be considered for follow-up evaluation of colorectal adenoma, especially those with adenoma at index colonoscopy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdenoma/complications*-
dc.subject.MESHAdenoma/diagnosis-
dc.subject.MESHAsymptomatic Diseases-
dc.subject.MESHCalcium/metabolism*-
dc.subject.MESHColonoscopy-
dc.subject.MESHColorectal Neoplasms/complications*-
dc.subject.MESHColorectal Neoplasms/diagnosis-
dc.subject.MESHCoronary Angiography/methods-
dc.subject.MESHCoronary Artery Disease/diagnosis-
dc.subject.MESHCoronary Artery Disease/epidemiology-
dc.subject.MESHCoronary Artery Disease/etiology*-
dc.subject.MESHCoronary Vessels/diagnostic imaging*-
dc.subject.MESHCoronary Vessels/metabolism-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultidetector Computed Tomography-
dc.subject.MESHROC Curve-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment/methods*-
dc.subject.MESHRisk Factors-
dc.subject.MESHVascular Calcification/diagnosis-
dc.subject.MESHVascular Calcification/epidemiology-
dc.subject.MESHVascular Calcification/etiology*-
dc.titleThe association between progression of coronary artery calcium and colorectal adenoma: A retrospective follow-up study of asymptomatic Koreans-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYun Jeong Lee-
dc.contributor.googleauthorSu Jung Baik-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorByoung Kwon Lee-
dc.identifier.doi10.1097/MD.0000000000017629-
dc.contributor.localIdA01636-
dc.contributor.localIdA01774-
dc.contributor.localIdA01774-
dc.contributor.localIdA04580-
dc.contributor.localIdA04580-
dc.contributor.localIdA02793-
dc.contributor.localIdA02793-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA04811-
dc.contributor.localIdA04811-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid31626147-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.affiliatedAuthor박재준-
dc.contributor.affiliatedAuthor박효진-
dc.contributor.affiliatedAuthor박효진-
dc.contributor.affiliatedAuthor백수정-
dc.contributor.affiliatedAuthor백수정-
dc.contributor.affiliatedAuthor이병권-
dc.contributor.affiliatedAuthor이병권-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor한동희-
dc.contributor.affiliatedAuthor한동희-
dc.citation.volume98-
dc.citation.number42-
dc.citation.startPagee17629-
dc.identifier.bibliographicCitationMEDICINE, Vol.98(42) : e17629, 2019-
dc.identifier.rimsid63734-
dc.type.rimsART-
Appears in Collections:
7. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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