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Potential clinical applications of terahertz radiation

Authors
 Joo-Hiuk Son  ;  Seung Jae Oh  ;  Hwayeong Cheon 
Citation
 JOURNAL OF APPLIED PHYSICS, Vol.125 : 190901, 2019 
Journal Title
JOURNAL OF APPLIED PHYSICS
ISSN
 0021-8979 
Issue Date
2019
Abstract
Terahertz radiation has significant potential in medical diagnosis and treatment because its frequency range corresponds to the characteristic
energy of biomolecular motion. Advantageously, terahertz-specific low energy does not cause the ionization of biomolecules. In this paper,
we review several state-of-the-art terahertz biomedical techniques and results and suggest potential techniques that may be applicable in
real-world clinics in the near future. First, some techniques for enhancing the penetration depth into wet biological tissues are surveyed.
Endoscopy and otoscopy methods for approaching internal organs are then discussed. The operation principles of sensors utilizing terahertz
radiation are explained, and certain sensing examples related to blood disorders, diabetes, and breathing conditions are presented. The greatest
potential of terahertz radiation in biomedical applications so far has been in cancer imaging, because terahertz radiation is ideal for measuring
the superficial soft tissues in which most cancers occur. The examples presented herein include skin, oral, gastric, breast, and brain cancers. In
search of a cancer-specific signal using terahertz radiation, methylated malignant DNA has been found to exhibit a characteristic resonance at
approximately 1.65 THz. This resonance may help treat cancer through the demethylation of malignant DNA using high-power terahertz irradiation
at this specific frequency, as well as serving as a potential cancer biomarker.
Full Text
https://aip.scitation.org/doi/full/10.1063/1.5080205#
DOI
10.1063/1.5080205
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Oh, Seung Jae(오승재)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173130
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