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Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis

Authors
 Seon-Sook Han  ;  Su Jin Lee  ;  Jae-Joon Yim  ;  Jin Hwa Song  ;  Eun Hye Lee  ;  Young Ae Kang 
Citation
 PLOS ONE, Vol.14(9) : e0222810, 2019 
Journal Title
 PLOS ONE 
Issue Date
2019
Abstract
OBJECTIVE: Healthcare workers (HCWs) are one of the target groups for systematic testing and treatment of latent tuberculosis infection (LTBI) in a setting of low TB incidence. We performed this study to describe the testing of HCWs for LTBI and analyse the acceptance and completion of treatment of LTBI. METHODS: This retrospective cohort study was conducted in four university-affiliated hospitals between January 1 and December 31, 2018. HCWs with positive interferon-gamma release assay (IGRA) during LTBI screening were analysed. We assessed the acceptance and completion of LTBI treatment. RESULTS: Overall, 893 HCWs were IGRA positive. Among them, 609 HCWs visited the clinic for evaluation of LTBI. Of 609 HCWs who were evaluated, 302 (49.6%) were offered treatment for LTBI. The proportion of acceptance for treatment was 64.5% (195 of 302 HCWs). The treatment course was completed by 143 of 195 HCWs (73.3%). Three months of isoniazid and rifampin (3HR) was used in 137 HCWs (70.3%) and 4 months of rifampin (4R) in 58 (29.7%). 72 HCWs (36.9%) experienced at least one adverse drug events, but there was no different characteristics between completer and non-completer. CONCLUSION: The acceptance and completion of LTBI treatment were unsatisfactory. Subjective perspective regarding obstacles to treatment of LTBI needs to be explored to increase compliance to LTBI treatment.
Files in This Item:
T201903896.pdf Download
DOI
10.1371/journal.pone.0222810
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Young Ae(강영애) ORCID logo https://orcid.org/0000-0002-7783-5271
Lee, Eun Hye(이은혜) ORCID logo https://orcid.org/0000-0003-2570-3442
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173093
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