Cited 13 times in
Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 이은혜 | - |
dc.date.accessioned | 2019-12-18T00:31:53Z | - |
dc.date.available | 2019-12-18T00:31:53Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173093 | - |
dc.description.abstract | OBJECTIVE: Healthcare workers (HCWs) are one of the target groups for systematic testing and treatment of latent tuberculosis infection (LTBI) in a setting of low TB incidence. We performed this study to describe the testing of HCWs for LTBI and analyse the acceptance and completion of treatment of LTBI. METHODS: This retrospective cohort study was conducted in four university-affiliated hospitals between January 1 and December 31, 2018. HCWs with positive interferon-gamma release assay (IGRA) during LTBI screening were analysed. We assessed the acceptance and completion of LTBI treatment. RESULTS: Overall, 893 HCWs were IGRA positive. Among them, 609 HCWs visited the clinic for evaluation of LTBI. Of 609 HCWs who were evaluated, 302 (49.6%) were offered treatment for LTBI. The proportion of acceptance for treatment was 64.5% (195 of 302 HCWs). The treatment course was completed by 143 of 195 HCWs (73.3%). Three months of isoniazid and rifampin (3HR) was used in 137 HCWs (70.3%) and 4 months of rifampin (4R) in 58 (29.7%). 72 HCWs (36.9%) experienced at least one adverse drug events, but there was no different characteristics between completer and non-completer. CONCLUSION: The acceptance and completion of LTBI treatment were unsatisfactory. Subjective perspective regarding obstacles to treatment of LTBI needs to be explored to increase compliance to LTBI treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seon-Sook Han | - |
dc.contributor.googleauthor | Su Jin Lee | - |
dc.contributor.googleauthor | Jae-Joon Yim | - |
dc.contributor.googleauthor | Jin Hwa Song | - |
dc.contributor.googleauthor | Eun Hye Lee | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 10.1371/journal.pone.0222810 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A03053 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 31536577 | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | 강영애 | - |
dc.contributor.affiliatedAuthor | 이은혜 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e0222810 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.14(9) : e0222810, 2019 | - |
dc.identifier.rimsid | 64388 | - |
dc.type.rims | ART | - |
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