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Diffusional kurtosis imaging for differentiation of additional suspicious lesions on preoperative breast MRI of patients with known breast cancer

DC FieldValueLanguage
dc.contributor.author김민정-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author박영진-
dc.contributor.author윤정현-
dc.date.accessioned2019-12-18T00:23:33Z-
dc.date.available2019-12-18T00:23:33Z-
dc.date.issued2019-
dc.identifier.issn0730-725X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173027-
dc.description.abstractPURPOSE: To investigate the potential of diffusional kurtosis imaging (DKI) and conventional diffusion-weighted imaging (DWI) in the evaluation of additional suspicious lesions at preoperative breast magnetic resonance imaging (MRI) in patients with breast cancer. MATERIALS AND METHODS: Fifty-three additional suspicious lesions in 45 patients with breast cancer, which were detected on preoperative breast MRI, were examined with a 3-T MR system. DKI and DWI data were obtained using a spin-echo single-shot echo-planar imaging sequence with b-values of 0, 50, 600, 1000, and 3000 s/mm2. Histogram parameters (mean, standard deviation, minimum, maximum, 10th, 25th, 50th, 75th, 90th percentiles, kurtosis, skewness and entropy) of ADC from DWI and diffusivity (D), kurtosis (K) from DKI were calculated after postprocessing. Parameters were compared between benign vs. ductal carcinoma in situ (DCIS) vs. invasive breast lesions and diagnostic performances were evaluated by receiver operating characteristic (ROC) analysis. Correlation between the mean values of D and K was analyzed according to lesion type. RESULTS: Multiple histogram parameters of D (mean, 25th, 50th percentile, 75th percentile, and entropy) differed between benign and invasive breast lesions (all P < 0.005), but none differed between benign vs. DCIS. D-90th percentile differed between DCIS vs. invasive cancer (P = 0.040). K-10th percentile differed between benign vs. DCIS (P = 0.015). ADC-75th percentile differed between benign vs. invasive cancer and ADC-75th percentile, ADC-90th percentile differed between DCIS vs. invasive cancer, respectively (all P < 0.005). ROC curve analysis showed high specificity for discrimination between benign and invasive cancer. D-mean and K-mean showed strong correlation in benign (rs = -0.813) and invasive lesions (rs = -0.853), but no significant correlation in DCIS. CONCLUSION: DKI may aid in the differentiation of additional suspicious lesions at preoperative breast MRI. Both ADC and DKI may have lower potential in differentiating DCIS from benign lesions.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfMAGNETIC RESONANCE IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDiffusional kurtosis imaging for differentiation of additional suspicious lesions on preoperative breast MRI of patients with known breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorVivian Youngjean Park-
dc.contributor.googleauthorSungheon G. Kim-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorMin Jung Kim-
dc.identifier.doi10.1016/j.mri.2019.07.011-
dc.contributor.localIdA00473-
dc.contributor.localIdA00801-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA01397-
dc.contributor.localIdA01572-
dc.contributor.localIdA01572-
dc.contributor.localIdA02595-
dc.contributor.localIdA02595-
dc.relation.journalcodeJ02178-
dc.identifier.eissn1873-5894-
dc.identifier.pmid31323316-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0730725X18303965-
dc.subject.keywordBreast-
dc.subject.keywordDiffusion-weighted imaging-
dc.subject.keywordDiffusional kurtosis imaging-
dc.subject.keywordMRI-
dc.subject.keywordPreoperative-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.affiliatedAuthor김민정-
dc.contributor.affiliatedAuthor김은경-
dc.contributor.affiliatedAuthor김은경-
dc.contributor.affiliatedAuthor문희정-
dc.contributor.affiliatedAuthor문희정-
dc.contributor.affiliatedAuthor박영진-
dc.contributor.affiliatedAuthor박영진-
dc.contributor.affiliatedAuthor윤정현-
dc.contributor.affiliatedAuthor윤정현-
dc.citation.volume62-
dc.citation.startPage199-
dc.citation.endPage208-
dc.identifier.bibliographicCitationMAGNETIC RESONANCE IMAGING, Vol.62 : 199-208, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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