Aliphatic radiofluorination using TBAHCO3 eluate in hydrous organic medium

Abstract

Azeotropic drying process is routinely applied to enhance nucleophilicity of [18F]fluoride ion during the nucleophilic production of PET radiotracers; however, the drying process requires usually 15–25 min. Due to the high demand of employing fluorine-18 (t1/2 = 109.8 min) in PET radiopharmaceutical production, several research groups have focused on the method development, obviating tedious removal process of the residual target water ([18O]H2O) for [18F]fluoride ion complex to be used in radiofluorination. Some development in radiofluorination in a mixed organic solvent system was demonstrated with various aliphatic substrates, but only kryptand as a phase transfer agent was utilized in the reported method. Here, we extend to investigate the development scope of applicability with basic alkyl ammonium salt as a phase transfer agent through the extensive elution efficiency study and radiofluorination outcome for aliphatic radiofluorination