45 90

Cited 0 times in

Aliphatic radiofluorination using TBAHCO3 eluate in hydrous organic medium

Authors
 Young-Do Kwon  ;  Jeongmin Son  ;  Joong-Hyun Chun 
Citation
 Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지), Vol.4(2) : 51-56, 2018 
Journal Title
 Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지) 
ISSN
 2384-1583 
Issue Date
2018
Keywords
Fluorine-18 ; Radiofluorination ; Phase transfer agent ; Radiotracer ; PET
Abstract
Azeotropic drying process is routinely applied to enhance nucleophilicity of $[^{18}F]$fluoride ion during the nucleophilic production of PET radiotracers; however, the drying process requires usually 15-25 min. Due to the high demand of employing fluorine-18 (t1/2=109.8min t1/2=109.8min ) in PET radiopharmaceutical production, several research groups have focused on the method development, obviating tedious removal process of the residual target water ($[^{18}O]H_2O$) for $[^{18}F]$fluoride ion complex to be used in radiofluorination. Some development in radiofluorination in a mixed organic solvent system was demonstrated with various aliphatic substrates, but only kryptand as a phase transfer agent was utilized in the reported method. Here, we extend to investigate the development scope of applicability with basic alkyl ammonium salt as a phase transfer agent through the extensive elution efficiency study and radiofluorination outcome for aliphatic radiofluorination.
Files in This Item:
T201806199.pdf Download
DOI
10.22643/JRMP.2018.4.2.51
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173005
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links