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Aliphatic radiofluorination using TBAHCO3 eluate in hydrous organic medium
DC Field | Value | Language |
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dc.contributor.author | 전중현 | - |
dc.date.accessioned | 2019-12-18T00:20:22Z | - |
dc.date.available | 2019-12-18T00:20:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2384-1583 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/173005 | - |
dc.description.abstract | Azeotropic drying process is routinely applied to enhance nucleophilicity of $[^{18}F]$fluoride ion during the nucleophilic production of PET radiotracers; however, the drying process requires usually 15-25 min. Due to the high demand of employing fluorine-18 (t1/2=109.8min t1/2=109.8min ) in PET radiopharmaceutical production, several research groups have focused on the method development, obviating tedious removal process of the residual target water ($[^{18}O]H_2O$) for $[^{18}F]$fluoride ion complex to be used in radiofluorination. Some development in radiofluorination in a mixed organic solvent system was demonstrated with various aliphatic substrates, but only kryptand as a phase transfer agent was utilized in the reported method. Here, we extend to investigate the development scope of applicability with basic alkyl ammonium salt as a phase transfer agent through the extensive elution efficiency study and radiofluorination outcome for aliphatic radiofluorination. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한방사선의약품학회 | - |
dc.relation.isPartOf | Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Aliphatic radiofluorination using TBAHCO3 eluate in hydrous organic medium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학교실) | - |
dc.contributor.googleauthor | Young-Do Kwon | - |
dc.contributor.googleauthor | Jeongmin Son | - |
dc.contributor.googleauthor | Joong-Hyun Chun | - |
dc.identifier.doi | 10.22643/JRMP.2018.4.2.51 | - |
dc.contributor.localId | A05406 | - |
dc.relation.journalcode | J03624 | - |
dc.identifier.eissn | 2508-3848 | - |
dc.subject.keyword | Fluorine-18 | - |
dc.subject.keyword | Radiofluorination | - |
dc.subject.keyword | Phase transfer agent | - |
dc.subject.keyword | Radiotracer | - |
dc.subject.keyword | PET | - |
dc.contributor.alternativeName | Chun, Joong-Hyun | - |
dc.contributor.affiliatedAuthor | 전중현 | - |
dc.citation.volume | 4 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 51 | - |
dc.citation.endPage | 56 | - |
dc.identifier.bibliographicCitation | Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지), Vol.4(2) : 51-56, 2018 | - |
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