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Quality of life in Korean patients with inflammatory bowel diseases: ulcerative colitis, Crohn's disease and intestinal Behçet's disease

Authors
 W. H. Kim  ;  Y. S. Cho  ;  H. M. Yoo  ;  I. S. Park  ;  E. C. Park  ;  J. G. Lim 
Citation
 INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol.14(1) : 52-57, 1999 
Journal Title
 INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 
ISSN
 0179-1958 
Issue Date
1999
MeSH
Base Sequence ; Bronchi/cytology ; Bronchi/drug effects* ; Bronchi/metabolism ; Cell Line ; DNA Primers ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology* ; Humans ; Mucins/genetics* ; Receptors, Retinoic Acid/physiology* ; Reverse Transcriptase Polymerase Chain Reaction ; Trachea/cytology ; Trachea/drug effects* ; Trachea/metabolism ; Transcriptional Activation ; Tretinoin/pharmacology*
Keywords
Quality of life ; Inflammatory Bowel Disease questionnaire ; Ulcerative colitis ; Crohn’s disease ; Intestinal Behcet’s disease
Abstract
Health-related quality of life (HRQOL) is an important outcome factor in chronic diseases such as inflammatory bowel disease (IBD). This study used the Korean translation of the disease-specific, self-administered Inflammatory Bowel Disease Questionnaire (IBDQ) to compare HRQOL in ulcerative colitis (UC; n = 98), Crohn's disease (CD; n = 49), and intestinal Behçet's disease (BD; n = 34). In addition to the current status, patients were asked retrospectively to recall their symptoms at the beginning and during the worst period of their disease. Disease activity was measured by St. Mark's Activity Index, Crohn's disease Activity Index (CDAI), and the Harvey-Bradshaw Index (HBI). In all IBD patients, including those with BD, the IBDQ total score during the worst period was significantly lower than that at present and that at the beginning of the disease. However, there were no significant differences between groups regarding the total IBDQ score or its various dimensions. In UC a strong correlation between IBDQ scores and St. Mark's Activity Index was observed (r = -0.708, P < 0.001). IBDQ scores were also highly correlated with CDAI and HBI in both CD (r = -0.506, P < 0.001 for CDAI; r = -0.600, P < 0.001 for HBI) and BD (r = -0.687, P < 0.001 for CDAI; r = -0.531, P < 0.001 for HBI). However, the current IBDQ score was not related to demographic parameters such as gender, age, educational status, economic status, and marital status as well as disease factors such as duration of disease, history of operation or hospital admission, extent of disease in UC, involved region in CD, and clinical type in BD. We conclude that the Korean IBDQ is a responsive and promising instrument for measuring HRQOL of IBD patients in clinical trials. In addition, the IBDQ can be helpful in developing a disease-specific activity index in BD.
Full Text
https://link.springer.com/article/10.1007%2Fs003840050183
DOI
10.1007/s003840050183
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172958
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