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한국의 Helicobactor pylori 감염 진단에서 상용혈청학적 검사 방법의 비교, 검토

Other Titles
 Comparison of Commercial Serologic Tests for Diagnosing Helicobacter pylori Infection in Korea 
Authors
 서정훈  ;  이용찬  ;  이준구  ;  안상훈  ;  문영명  ;  강진경  ;  박인서  ;  김현숙 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.34(5) : 582-592, 1999 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
1999
Keywords
Helicobacter pylori ; Serology ; ELISA
Abstract
Background/Aims : Various commercial serologic tests have been developed for the diagnosis of Helicobacter pylori (H. pylori) infection, but clinical data regarding their accuracies are often lacking. Methods : Sixty-four patients who visited Severance Hospital and underwent gastroscopy were enrolled. Multiple biopsy specimens were obtained from antrum and body for histology and rapid urease test (CLO test). As serologic tests, QuickVue, EZ-HP, GAP, Cobas Core II, and Pyloragen tests were used. Results : H. pylori infection were diagnosed in 40 (62.5%) patients by histology or CLO test. The sensitivities of five serologic tests were as follows: QuickVue, 75.0%; EZ-HP, 90.0%; GAP, 85.0%; Cobas Core Ⅱ, 80.0%; Pyloragen test, 80.0%. The specificities of those tests were as follows : QuickVue, 66,7%; EZ-HP, 45.8%; GAP, 62.5%; Cobas Core Ⅱ, 70.8%; Pyloragen, 70.8%. The accuracies of them were as follows: QuickVue, 77.5%; EZ-HP, 73.4%; GAP, 85.0%; Cobas Core Ⅱ, 76.6%; Pyloragen, 76.6%. The five serologic tests showed no statistically significant difference in their sensitivity and specificity. The QuickVue and the EZ-HP were comparable in their accuracy. However, the EZ-HP test revealed higher sensitivity and lower specificity than the QuickVue test. The GAP test showed better sensitivity compared to those of other quantitative tests, but all of them were comparable in terms of poor specificities. Conclusions: The five serologic tests showed lower specificities in Korea than in western countries. Thus, the development of serologic tests with good diagnostic accuracy is necessary in Korea.
Files in This Item:
T199903280.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172923
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