0 16

Cited 0 times in

혈장 PAI-1, Factor Ⅶ 및 섬유소원 농도와 관상동맥질환의 연관성

Other Titles
 Association of Plasma Levels of PAI-1 , Factor Ⅶ and Fibrinogen with Coronary Artery Disease 
Authors
 김현경  ;  송경순  ;  윤영섭  ;  심원흠  ;  고은나  ;  지선하 
Citation
 Korean Journal of Hematosis and Thrombosis (한국지혈혈전학회지), Vol.6(1) : 43-48, 1999 
Journal Title
 Korean Journal of Hematosis and Thrombosis (한국지혈혈전학회지) 
ISSN
 1225-7990 
Issue Date
1999
Keywords
Fibrinogen ; PAI-1 ; Factor Ⅶ ; Coronary Artery Disease ; Risk Factor
Abstract
Background : The contribution of coagulation factors and fibrinolytic variables to the development of coronary artery disease(CAD) is still not clearly established. The aim of this study is to evaluate the role of plasma plasminogen activator inhibitor-1(PAI 1), factor Ⅶ(FⅦ) and fibrinogen as a determinant for CAD in case-control study of the middle-aged men and women. Methods : We measured plasma PAI-1, FⅦ and fibrinogen in 106 patients with CAD and in 107 healthy controls. Un Paired t-test and multivariate logistic regression analysis were performed to assess the risk factors for CAD. Results : Mean levels of plasma fibrinogen in patients and controls were 371.8±110.6 ㎎/dL and 296.3±74.4 ㎎/dL (P<0.001), respectively. There was no significant difference between patients and controls in the levels of plasma PAI-1, FⅦ. The odds ratios of CAD for and standard deviation increment in PAI-1, FⅦ and fibrinogen wee 1.04, 0.79 and 2.62 respectively. Women with CAD had higher levels of PAI-1 than those without CAD (12.9±7.4ng/mL vs 9.9±6.4ng/mL). Conclusions : These results indicate that increased levels of fibrinogen is an independent risk factor for CAD. PAI-1 levels in women were found to be associated with the CAD.
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172913
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse