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혈장 PAI-1, Factor Ⅶ 및 섬유소원 농도와 관상동맥질환의 연관성

Other Titles
 Association of Plasma Levels of PAI-1 , Factor Ⅶ and Fibrinogen with Coronary Artery Disease 
 김현경  ;  송경순  ;  윤영섭  ;  심원흠  ;  고은나  ;  지선하 
 Korean Journal of Hematosis and Thrombosis (한국지혈혈전학회지), Vol.6(1) : 43-48, 1999 
Journal Title
Korean Journal of Hematosis and Thrombosis(한국지혈혈전학회지)
Issue Date
Fibrinogen ; PAI-1 ; Factor Ⅶ ; Coronary Artery Disease ; Risk Factor
Background : The contribution of coagulation factors and fibrinolytic variables to the
development of coronary artery disease(CAD) is still not clearly established. The aim of
this study is to evaluate the role of plasma plasminogen activator inhibitor-1(PAI 1),
factor Ⅶ(FⅦ) and fibrinogen as a determinant for CAD in case-control study of the
middle-aged men and women.
Methods : We measured plasma PAI-1, FⅦ and fibrinogen in 106 patients with CAD
and in 107 healthy controls. Un Paired t-test and multivariate logistic regression
analysis were performed to assess the risk factors for CAD.
Results : Mean levels of plasma fibrinogen in patients and controls were 371.8±110.6
㎎/dL and 296.3±74.4 ㎎/dL (P<0.001), respectively. There was no significant difference
between patients and controls in the levels of plasma PAI-1, FⅦ. The odds ratios of
CAD for and standard deviation increment in PAI-1, FⅦ and fibrinogen wee 1.04, 0.79
and 2.62 respectively. Women with CAD had higher levels of PAI-1 than those without
CAD (12.9±7.4ng/mL vs 9.9±6.4ng/mL).
Conclusions : These results indicate that increased levels of fibrinogen is an
independent risk factor for CAD. PAI-1 levels in women were found to be associated
with the CAD.
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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