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혈장 PAI-1, Factor Ⅶ 및 섬유소원 농도와 관상동맥질환의 연관성

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dc.contributor.author지선하-
dc.date.accessioned2019-11-26T01:18:19Z-
dc.date.available2019-11-26T01:18:19Z-
dc.date.issued1999-
dc.identifier.issn1225-7990-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/172913-
dc.description.abstractBackground : The contribution of coagulation factors and fibrinolytic variables to the development of coronary artery disease(CAD) is still not clearly established. The aim of this study is to evaluate the role of plasma plasminogen activator inhibitor-1(PAI 1), factor Ⅶ(FⅦ) and fibrinogen as a determinant for CAD in case-control study of the middle-aged men and women. Methods : We measured plasma PAI-1, FⅦ and fibrinogen in 106 patients with CAD and in 107 healthy controls. Un Paired t-test and multivariate logistic regression analysis were performed to assess the risk factors for CAD. Results : Mean levels of plasma fibrinogen in patients and controls were 371.8±110.6 ㎎/dL and 296.3±74.4 ㎎/dL (P<0.001), respectively. There was no significant difference between patients and controls in the levels of plasma PAI-1, FⅦ. The odds ratios of CAD for and standard deviation increment in PAI-1, FⅦ and fibrinogen wee 1.04, 0.79 and 2.62 respectively. Women with CAD had higher levels of PAI-1 than those without CAD (12.9±7.4ng/mL vs 9.9±6.4ng/mL). Conclusions : These results indicate that increased levels of fibrinogen is an independent risk factor for CAD. PAI-1 levels in women were found to be associated with the CAD.-
dc.description.statementOfResponsibilityprohibition-
dc.languageKorean-
dc.publisher한국지혈혈전학회-
dc.relation.isPartOfKorean Journal of Hematosis and Thrombosis (한국지혈혈전학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title혈장 PAI-1, Factor Ⅶ 및 섬유소원 농도와 관상동맥질환의 연관성-
dc.title.alternativeAssociation of Plasma Levels of PAI-1 , Factor Ⅶ and Fibrinogen with Coronary Artery Disease-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthor김현경-
dc.contributor.googleauthor송경순-
dc.contributor.googleauthor윤영섭-
dc.contributor.googleauthor심원흠-
dc.contributor.googleauthor고은나-
dc.contributor.googleauthor지선하-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ03704-
dc.subject.keywordFibrinogen-
dc.subject.keywordPAI-1-
dc.subject.keywordFactor Ⅶ-
dc.subject.keywordCoronary Artery Disease-
dc.subject.keywordRisk Factor-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume6-
dc.citation.number1-
dc.citation.startPage43-
dc.citation.endPage48-
dc.identifier.bibliographicCitationKorean Journal of Hematosis and Thrombosis (한국지혈혈전학회지), Vol.6(1) : 43-48, 1999-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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