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Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells
- Authors
- So-Yeop Han ; So-Hye Cho ; So-Yeon Kim ; Jeong-Taeg Seo ; Seok-Jun Moon ; Gil-Ja Jhon
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.9(1) : 59-64, 1999
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ISSN
- 0960-894X
- Issue Date
- 1999
- MeSH
- Acetylcholine/pharmacology ; Animals ; Calcium/metabolism* ; Calcium Signaling/drug effects ; Diglycerides/chemical synthesis ; Diglycerides/chemistry* ; Diglycerides/pharmacology* ; Molecular Structure ; Pancreas/cytology ; Pancreas/drug effects* ; Pancreas/metabolism ; Rats ; Structure-Activity Relationship
- Abstract
- Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.
- Appears in Collections:
- 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
- Yonsei Authors
-
Moon, Seok Jun(문석준)
https://orcid.org/0000-0001-7282-2888
Seo, Jeong Taeg(서정택) https://orcid.org/0000-0003-2697-0251
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