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Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells

Authors
 So-Yeop Han  ;  So-Hye Cho  ;  So-Yeon Kim  ;  Jeong-Taeg Seo  ;  Seok-Jun Moon  ;  Gil-Ja Jhon 
Citation
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.9(1) : 59-64, 1999 
Journal Title
 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 
ISSN
 0960-894X 
Issue Date
1999
MeSH
Acetylcholine/pharmacology ; Animals ; Calcium/metabolism* ; Calcium Signaling/drug effects ; Diglycerides/chemical synthesis ; Diglycerides/chemistry* ; Diglycerides/pharmacology* ; Molecular Structure ; Pancreas/cytology ; Pancreas/drug effects* ; Pancreas/metabolism ; Rats ; Structure-Activity Relationship
Abstract
Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.
Full Text
https://www.sciencedirect.com/science/article/pii/S0960894X98006908
DOI
10.1016/s0960-894x(98)00690-8
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172790
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